| RTW Investments, LP | Institution | 6.576.306 | 7,48% | US$ 25,38M | 2026-03-31 |
| BlackRock, Inc. | Institution | 6.194.925 | 7,05% | US$ 23,91M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 5.740.850 | 6,53% | US$ 22,16M | 2026-03-31 |
| Armistice Capital LLC | Institution | 4.592.000 | 5,23% | US$ 17,73M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.849.390 | 4,38% | US$ 14,86M | 2025-11-21 |
| Nantahala Capital Management, LLC | Institution | 3.584.820 | 4,08% | US$ 13,84M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3.516.651 | 4,00% | US$ 13,57M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 3.425.000 | 3,90% | US$ 13,22M | 2025-07-21 |
| Point72 Associates, LLC | Institution | 3.338.419 | 3,80% | US$ 12,89M | 2025-07-25 |
| Vanguard Capital Management, LLC | Institution | 3.322.770 | 3,78% | US$ 12,83M | 2026-03-31 |
| Stonepine Capital Management LLC | Institution | 3.302.300 | 3,76% | US$ 12,75M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 3.146.631 | 3,58% | US$ 12,15M | 2026-03-31 |
| Foresite Capital Fund VI LP | Institution | 3.146.631 | 3,58% | US$ 12,15M | 2026-03-31 |
| Stonepine Capital, L.P. | Institution | 2.670.032 | 3,04% | US$ 10,31M | 2025-09-30 |
| Millennium Management LLC | Institution | 2.411.965 | 2,74% | US$ 9,31M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.308.669 | 2,63% | US$ 8,91M | 2026-03-31 |
| Morgan Stanley | Institution | 2.217.366 | 2,52% | US$ 8,56M | 2026-03-31 |
| Rosalind Advisors, Inc. | Institution | 2.138.475 | 2,43% | US$ 8,25M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 2.050.000 | 2,33% | US$ 7,91M | 2026-03-31 |
| AIGH Investment Partners | Institution | 2.003.179 | 2,28% | US$ 7,73M | 2025-06-30 |
| Aigh Capital Management, LLC | Institution | 2.000.000 | 2,28% | US$ 7,72M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.717.557 | 1,95% | US$ 6,63M | 2026-03-31 |
| J. Goldman & Co., L.P. | Institution | 1.680.752 | 1,91% | US$ 6,49M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 1.476.028 | 1,68% | US$ 5,70M | 2026-03-31 |
| Acorn Bioventures | Institution | 1.469.153 | 1,67% | US$ 5,67M | 2026-03-31 |
| Nextbio Capital Management Lp | Institution | 1.306.800 | 1,49% | US$ 5,04M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.262.112 | 1,44% | US$ 4,87M | 2026-03-31 |
| Atlas Diversified Master Fund, Ltd. | Institution | 1.217.534 | 1,39% | US$ 4,70M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1.105.021 | 1,26% | US$ 4,27M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1.000.000 | 1,14% | US$ 3,86M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 820.000 | 0,93% | US$ 3,17M | 2026-03-31 |
| Longaeva Partners L.P. | Institution | 807.755 | 0,92% | US$ 3,12M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 756.875 | 0,86% | US$ 2,92M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 667.010 | 0,76% | US$ 2,57M | 2026-03-31 |
| Exome Asset Management LLC | Institution | 636.700 | 0,72% | US$ 2,46M | 2026-03-31 |
| Soleus Capital Master Fund, L.P. | Institution | 592.300 | 0,67% | US$ 2,29M | 2025-03-31 |
| Baker Bros. Advisors LP | Institution | 584.757 | 0,67% | US$ 2,26M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 570.618 | 0,65% | US$ 2,20M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 556.016 | 0,63% | US$ 2,15M | 2026-03-31 |
| UBS Asset Management AG | Institution | 545.541 | 0,62% | US$ 2,11M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 515.786 | 0,59% | US$ 1,99M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 494.694 | 0,56% | US$ 1,91M | 2026-03-31 |
| Synovus Trust Company, National Association | Institution | 488.446 | 0,56% | US$ 1,89M | 2026-03-31 |