| Vivo Capital, LLC | Institution | 1.789.916 | 6,70% | US$ 9,41M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.399.348 | 5,24% | US$ 7,36M | 2026-03-31 |
| Biomedical Value Fund | Institution | 1.098.000 | 4,11% | US$ 5,78M | 2024-12-31 |
| Octagon Capital Advisors LP | Institution | 1.000.000 | 3,75% | US$ 5,26M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 939.202 | 3,52% | US$ 4,94M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 811.430 | 3,04% | US$ 4,27M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 796.558 | 2,98% | US$ 4,19M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 650.000 | 2,43% | US$ 3,42M | 2025-12-31 |
| Dr. Shalabh Gupta | Insider | 597.246 | 2,24% | US$ 3,14M | 2025-04-30 |
| Logos Global Management, L.P. | Institution | 473.563 | 1,77% | US$ 2,49M | 2026-03-31 |
| Octagon Biotech Opportunities Fund I LP | Institution | 350.000 | 1,31% | US$ 1,84M | 2025-12-31 |
| Octagon Private Opportunities Fund II LP | Institution | 350.000 | 1,31% | US$ 1,84M | 2025-06-30 |
| Citadel Advisors LLC | Institution | 236.841 | 0,89% | US$ 1,25M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 225.000 | 0,84% | US$ 1,18M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 203.744 | 0,76% | US$ 1,07M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 199.219 | 0,75% | US$ 1,05M | 2026-03-31 |
| Morgan Stanley | Institution | 188.182 | 0,70% | US$ 989,84k | 2026-03-31 |
| Marshall Wace LLP | Institution | 154.938 | 0,58% | US$ 814,97k | 2026-03-31 |
| Dauntless Investment Group, Llc | Institution | 147.087 | 0,55% | US$ 773,68k | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 143.052 | 0,54% | US$ 752,45k | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 119.531 | 0,45% | US$ 628,73k | 2026-03-31 |
| Diadema Partners LP | Institution | 106.083 | 0,40% | US$ 558,00k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 101.074 | 0,38% | US$ 531,65k | 2026-03-31 |
| Diametric Capital, LP | Institution | 80.362 | 0,30% | US$ 422,70k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 80.027 | 0,30% | US$ 420,94k | 2026-03-31 |
| Cantor Fitzgerald Asset Management | Institution | 75.000 | 0,28% | US$ 394,50k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 72.243 | 0,27% | US$ 380,00k | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 57.959 | 0,22% | US$ 304,86k | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 55.700 | 0,21% | US$ 292,98k | 2026-03-31 |
| Barclays Bank Plc | Institution | 50.000 | 0,19% | US$ 263,00k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 41.492 | 0,16% | US$ 218,25k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 35.937 | 0,13% | US$ 189,03k | 2026-03-31 |
| BlackRock, Inc. | Institution | 35.903 | 0,13% | US$ 188,85k | 2026-03-31 |
| OMERS Administration Corporation | Institution | 31.900 | 0,12% | US$ 167,79k | 2026-03-31 |
| Bank of America Corporation | Institution | 29.530 | 0,11% | US$ 155,33k | 2026-03-31 |
| Quadrature Capital Limited | Institution | 27.917 | 0,10% | US$ 146,84k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 27.093 | 0,10% | US$ 142,51k | 2026-03-31 |
| Persistent Asset Partners Limited | Institution | 26.827 | 0,10% | US$ 141,11k | 2026-03-31 |
| Virtu Financial, Inc. | Institution | 26.274 | 0,10% | US$ 138,20k | 2026-03-31 |