| RA Capital Management, L.P. | Institution | 12.198.625 | 20,51% | US$ 397,31M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 10.259.291 | 17,25% | US$ 334,15M | 2026-03-04 |
| FMR LLC | Institution | 7.747.629 | 13,03% | US$ 252,34M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 4.055.861 | 6,82% | US$ 132,10M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.890.589 | 6,54% | US$ 126,72M | 2026-03-31 |
| Alta Partners Nextgen Fund II, L.P. | Institution | 3.823.425 | 6,43% | US$ 124,53M | 2025-12-19 |
| Alta Partners LP | Institution | 3.823.425 | 6,43% | US$ 124,53M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 3.580.818 | 6,02% | US$ 116,63M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 3.248.980 | 5,46% | US$ 105,82M | 2026-03-31 |
| The Column Group, LLC | Institution | 2.898.103 | 4,87% | US$ 94,39M | 2025-02-27 |
| TCG Crossover Fund I, L.P. | Institution | 2.898.103 | 4,87% | US$ 94,39M | 2025-02-27 |
| Commodore Capital Master LP | Institution | 2.750.000 | 4,62% | US$ 89,57M | 2025-05-07 |
| Commodore Capital LP | Institution | 2.475.000 | 4,16% | US$ 80,61M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.217.929 | 3,73% | US$ 72,24M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 2.054.991 | 3,46% | US$ 66,93M | 2026-03-31 |
| BVF Partners L.P. | Institution | 1.976.196 | 3,32% | US$ 64,36M | 2026-03-31 |
| RA Capital Nexus Fund, L.P. | Institution | 1.496.613 | 2,52% | US$ 48,74M | 2026-03-04 |
| Farallon Capital Offshore Investors II, L.P | Institution | 1.452.596 | 2,44% | US$ 47,31M | 2026-03-31 |
| Dr. Todd Harris | Insider | 1.358.631 | 2,28% | US$ 44,25M | 2026-05-05 |
| Caligan Partners, LP | Institution | 1.276.968 | 2,15% | US$ 41,59M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.216.078 | 2,04% | US$ 39,61M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.135.053 | 1,91% | US$ 36,97M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 1.125.970 | 1,89% | US$ 36,67M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 1.029.298 | 1,73% | US$ 33,52M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 986.061 | 1,66% | US$ 32,12M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 850.000 | 1,43% | US$ 27,68M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 829.908 | 1,40% | US$ 27,03M | 2025-12-31 |
| Barclays PLC | Institution | 808.077 | 1,36% | US$ 26,32M | 2026-03-31 |
| Canaan Management, Inc. | Institution | 750.000 | 1,26% | US$ 24,43M | 2026-03-31 |
| Canaan XI | Institution | 750.000 | 1,26% | US$ 24,43M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 739.107 | 1,24% | US$ 24,07M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 658.482 | 1,11% | US$ 21,45M | 2026-03-31 |
| Jennison Associates LLC | Institution | 632.432 | 1,06% | US$ 20,60M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 605.439 | 1,02% | US$ 19,72M | 2026-03-31 |
| Farallon Capital Partners, L.P. | Institution | 579.376 | 0,97% | US$ 18,87M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 549.000 | 0,92% | US$ 17,88M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 526.604 | 0,89% | US$ 17,15M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 351.479 | 0,59% | US$ 11,45M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 350.000 | 0,59% | US$ 11,40M | 2026-03-31 |