| RA Capital Management, L.P. | Institution | 23.555.648 | 8,20% | US$ 149,34M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 23.555.648 | 8,20% | US$ 149,34M | 2025-09-30 |
| Avoro Capital Advisors LLC | Institution | 21.700.000 | 7,55% | US$ 137,58M | 2026-03-31 |
| BlackRock, Inc. | Institution | 18.365.608 | 6,39% | US$ 116,44M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 18.000.000 | 6,26% | US$ 114,12M | 2026-03-31 |
| Morgan Stanley | Institution | 17.926.057 | 6,24% | US$ 113,65M | 2026-03-31 |
| FMR LLC | Institution | 14.320.767 | 4,98% | US$ 90,79M | 2026-03-31 |
| RTW Investments, LP | Institution | 13.680.248 | 4,76% | US$ 86,73M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 13.273.942 | 4,62% | US$ 84,16M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 11.209.078 | 3,90% | US$ 71,07M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 10.450.000 | 3,64% | US$ 66,25M | 2024-12-31 |
| Vanguard Capital Management, LLC | Institution | 10.231.502 | 3,56% | US$ 64,87M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 9.095.703 | 3,17% | US$ 57,67M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 8.859.911 | 3,08% | US$ 56,17M | 2026-03-31 |
| Artal Group S.A. | Institution | 8.829.913 | 3,07% | US$ 55,98M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 6.397.200 | 2,23% | US$ 40,56M | 2024-09-30 |
| Polar Capital Holdings Plc | Institution | 5.654.340 | 1,97% | US$ 35,85M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 5.531.955 | 1,93% | US$ 35,07M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 4.427.301 | 1,54% | US$ 28,07M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 4.004.756 | 1,39% | US$ 25,39M | 2026-03-31 |
| Tybourne Capital Management (HK) Ltd. | Institution | 3.700.000 | 1,29% | US$ 23,46M | 2025-09-30 |
| Millennium Management LLC | Institution | 3.281.820 | 1,14% | US$ 20,81M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 3.250.000 | 1,13% | US$ 20,61M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.979.429 | 1,04% | US$ 18,89M | 2026-03-31 |
| Healthcare of Ontario Pension Plan Trust Fund | Institution | 2.883.301 | 1,00% | US$ 18,28M | 2026-03-31 |
| Tiger Lily Capital | Institution | 2.863.704 | 1,00% | US$ 18,16M | 2025-05-30 |
| Barclays PLC | Institution | 2.809.041 | 0,98% | US$ 17,81M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 2.722.165 | 0,95% | US$ 17,26M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.366.099 | 0,82% | US$ 15,00M | 2024-09-30 |
| SG Americas Securities, LLC | Institution | 2.176.742 | 0,76% | US$ 13,80M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 2.022.498 | 0,70% | US$ 12,82M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 1.944.671 | 0,68% | US$ 12,33M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.837.800 | 0,64% | US$ 11,65M | 2025-12-31 |
| Northern Trust Global Investments | Institution | 1.814.318 | 0,63% | US$ 11,50M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.808.599 | 0,63% | US$ 11,47M | 2026-03-31 |
| The B Group, Inc. | Institution | 1.800.556 | 0,63% | US$ 11,42M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.677.046 | 0,58% | US$ 10,63M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.530.461 | 0,53% | US$ 9,70M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 1.391.382 | 0,48% | US$ 8,82M | 2026-03-31 |