| Janus Henderson Group plc | Institution | 1.815.474 | 3,55% | US$ 31,55M | 2026-03-31 |
| VR Management, LLC | Institution | 1.675.262 | 3,28% | US$ 29,12M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.447.782 | 2,83% | US$ 25,16M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.347.130 | 2,64% | US$ 23,41M | 2026-05-18 |
| Ikarian Healthcare Master Fund, L.P. | Institution | 1.017.600 | 1,99% | US$ 17,69M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 1.017.600 | 1,99% | US$ 17,69M | 2026-03-31 |
| Stonepine Capital Management LLC | Institution | 975.200 | 1,91% | US$ 16,95M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 800.000 | 1,57% | US$ 13,90M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 800.000 | 1,57% | US$ 13,90M | 2026-03-31 |
| Morgan Stanley | Institution | 596.564 | 1,17% | US$ 10,37M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 586.990 | 1,15% | US$ 10,20M | 2026-05-31 |
| Velan Capital Partners LP | Institution | 583.333 | 1,14% | US$ 10,14M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 569.308 | 1,11% | US$ 9,89M | 2025-12-31 |
| Adage Capital Management, L.P. | Institution | 540.126 | 1,06% | US$ 9,39M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 533.965 | 1,05% | US$ 9,28M | 2026-03-31 |
| Armistice Capital LLC | Institution | 478.827 | 0,94% | US$ 8,32M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 448.475 | 0,88% | US$ 7,79M | 2026-03-31 |
| Artal Group S.A. | Institution | 427.141 | 0,84% | US$ 7,42M | 2026-03-31 |
| TD Asset Management, Inc. | Institution | 399.184 | 0,78% | US$ 6,94M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 396.642 | 0,78% | US$ 6,89M | 2025-03-31 |
| Dellora Investments LP | Institution | 394.665 | 0,77% | US$ 6,86M | 2026-03-31 |
| UBS Asset Management AG | Institution | 381.419 | 0,75% | US$ 6,63M | 2026-03-31 |
| RTW Investments, LP | Institution | 370.246 | 0,72% | US$ 6,43M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 366.791 | 0,72% | US$ 6,37M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 366.143 | 0,72% | US$ 6,36M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 361.108 | 0,71% | US$ 6,28M | 2025-09-30 |
| Marshall Wace LLP | Institution | 352.572 | 0,69% | US$ 6,13M | 2026-03-31 |
| Dellora Investments Master Fund LP | Institution | 345.257 | 0,68% | US$ 6,00M | 2026-03-31 |
| BVF Partners L.P. | Institution | 339.549 | 0,66% | US$ 5,90M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 327.307 | 0,64% | US$ 5,69M | 2026-03-31 |
| Woodline Partners LP | Institution | 323.911 | 0,63% | US$ 5,63M | 2026-03-31 |
| FMR LLC | Institution | 322.600 | 0,63% | US$ 5,61M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 279.537 | 0,55% | US$ 4,86M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 263.421 | 0,52% | US$ 4,58M | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 215.934 | 0,42% | US$ 3,75M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 213.462 | 0,42% | US$ 3,71M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 208.333 | 0,41% | US$ 3,62M | 2026-03-31 |
| Boone Capital Management LLC | Institution | 200.000 | 0,39% | US$ 3,48M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 194.616 | 0,38% | US$ 3,38M | 2026-03-31 |
| StemPoint Capital LP | Institution | 188.700 | 0,37% | US$ 3,28M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 185.546 | 0,36% | US$ 3,22M | 2026-03-31 |
| Diadema Partners LP | Institution | 179.738 | 0,35% | US$ 3,12M | 2026-03-31 |
| RTW Master Fund, Ltd. | Institution | 175.545 | 0,34% | US$ 3,05M | 2025-04-14 |
| Integral Health Asset Management, LLC | Institution | 167.000 | 0,33% | US$ 2,90M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 152.600 | 0,30% | US$ 2,65M | 2026-03-31 |