| Deep Track Capital, LP | Institution | 3.600.000 | 8,37% | US$ 238,21M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.552.612 | 8,26% | US$ 235,08M | 2026-03-31 |
| RTW Investments, LP | Institution | 3.346.025 | 7,78% | US$ 221,41M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.000.000 | 6,97% | US$ 198,51M | 2025-09-30 |
| Paradigm Biocapital Advisors LP | Institution | 2.562.154 | 5,96% | US$ 169,54M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.240.963 | 5,21% | US$ 148,28M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 2.094.428 | 4,87% | US$ 138,59M | 2024-09-30 |
| Morgan Stanley | Institution | 1.868.677 | 4,34% | US$ 123,65M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.760.541 | 4,09% | US$ 116,49M | 2026-03-31 |
| Jennison Associates LLC | Institution | 1.712.124 | 3,98% | US$ 113,29M | 2026-03-31 |
| Frazier Life Sciences IX, L.P. | Institution | 1.587.527 | 3,69% | US$ 105,05M | 2024-09-30 |
| Assenagon Asset Management S.A. | Institution | 1.280.194 | 2,98% | US$ 84,71M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.188.624 | 2,76% | US$ 78,65M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.121.091 | 2,61% | US$ 74,18M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 978.212 | 2,27% | US$ 64,73M | 2026-03-31 |
| Bank of America Corporation | Institution | 948.071 | 2,20% | US$ 62,73M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 926.125 | 2,15% | US$ 61,28M | 2026-03-31 |
| Dr. Bobak Azamian | Insider | 891.412 | 2,07% | US$ 58,98M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 842.313 | 1,96% | US$ 55,74M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 821.962 | 1,91% | US$ 54,39M | 2025-12-31 |
| D. E. Shaw & Co., L.P. | Institution | 791.146 | 1,84% | US$ 52,35M | 2026-03-31 |
| Tang Capital Partners International, LP | Institution | 784.938 | 1,82% | US$ 51,94M | 2025-12-31 |
| FMR LLC | Institution | 733.270 | 1,70% | US$ 48,52M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 728.644 | 1,69% | US$ 48,21M | 2026-03-31 |
| Invesco Ltd. | Institution | 570.110 | 1,33% | US$ 37,72M | 2026-03-31 |
| Millennium Management LLC | Institution | 564.579 | 1,31% | US$ 37,36M | 2026-03-31 |
| ClearBridge Investments, LLC | Institution | 545.351 | 1,27% | US$ 36,09M | 2026-03-31 |
| The Toronto-Dominion Bank | Institution | 510.253 | 1,19% | US$ 33,76M | 2026-03-31 |
| Nomura Investment Management Business Trust | Institution | 499.853 | 1,16% | US$ 33,08M | 2026-03-31 |
| Loomis Sayles & Company, L.P. | Institution | 407.836 | 0,95% | US$ 26,99M | 2026-03-31 |
| TimesSquare Capital Management, LLC | Institution | 388.590 | 0,90% | US$ 25,71M | 2026-03-31 |
| Tang Capital Partners, LP | Institution | 360.186 | 0,84% | US$ 23,83M | 2025-12-31 |
| Northern Trust Global Investments | Institution | 352.957 | 0,82% | US$ 23,36M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 335.889 | 0,78% | US$ 22,23M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 332.982 | 0,77% | US$ 22,03M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 329.750 | 0,77% | US$ 21,82M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 328.162 | 0,76% | US$ 21,71M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 324.014 | 0,75% | US$ 21,44M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 307.307 | 0,71% | US$ 20,33M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 303.509 | 0,71% | US$ 20,08M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 299.957 | 0,70% | US$ 19,85M | 2026-03-31 |