| T. Rowe Price Group, Inc. | Institution | 11.648.346 | 15,19% | US$ 75,02M | 2026-03-31 |
| Redmile Group, LLC | Institution | 6.892.033 | 8,99% | US$ 44,38M | 2026-06-09 |
| OrbiMed Advisors LLC | Institution | 6.306.127 | 8,22% | US$ 40,61M | 2026-06-15 |
| OrbiMed Private Investments IX, LP | Institution | 5.255.106 | 6,85% | US$ 33,84M | 2026-06-15 |
| Prosight Management, LP | Institution | 5.004.439 | 6,53% | US$ 32,23M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 4.644.957 | 6,06% | US$ 29,91M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.706.734 | 4,83% | US$ 23,87M | 2026-06-10 |
| Deep Track Capital, LP | Institution | 3.706.734 | 4,83% | US$ 23,87M | 2026-06-10 |
| Redmile Biopharma Investments II, L.P. | Institution | 3.338.997 | 4,35% | US$ 21,50M | 2026-06-09 |
| Nextbio Capital Management Lp | Institution | 3.149.907 | 4,11% | US$ 20,29M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.277.176 | 2,97% | US$ 14,67M | 2026-03-31 |
| Prosight Plus Fund, LP | Institution | 1.573.872 | 2,05% | US$ 10,14M | 2024-09-30 |
| Clark Estates Inc. | Institution | 1.475.648 | 1,92% | US$ 9,50M | 2026-03-31 |
| Pinnacle Associates, Ltd. | Institution | 1.368.223 | 1,78% | US$ 8,81M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 1.159.321 | 1,51% | US$ 7,47M | 2026-03-31 |
| OrbiMed Genesis Master Fund, L.P. | Institution | 1.051.021 | 1,37% | US$ 6,77M | 2026-06-15 |
| Point72 Asset Management, L.P. | Institution | 1.031.049 | 1,34% | US$ 6,64M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 905.707 | 1,18% | US$ 5,83M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 800.000 | 1,04% | US$ 5,15M | 2026-03-31 |
| Millennium Management LLC | Institution | 763.745 | 1,00% | US$ 4,92M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 715.965 | 0,93% | US$ 4,61M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 645.705 | 0,84% | US$ 4,16M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 604.500 | 0,79% | US$ 3,89M | 2026-03-31 |
| Marshall Wace LLP | Institution | 581.471 | 0,76% | US$ 3,74M | 2026-03-31 |
| Takeda Pharmaceutical Company Limited | Institution | 515.619 | 0,67% | US$ 3,32M | 2025-09-30 |
| BlackRock, Inc. | Institution | 510.806 | 0,67% | US$ 3,29M | 2026-03-31 |
| Redmile Capital Offshore Master Fund, Ltd. | Institution | 494.932 | 0,65% | US$ 3,19M | 2025-08-25 |
| Prosight Fund, LP | Institution | 474.159 | 0,62% | US$ 3,05M | 2024-09-30 |
| Redmile Strategic Trading Sub, Ltd. | Institution | 467.910 | 0,61% | US$ 3,01M | 2025-08-25 |
| Redmile Capital Fund, LP | Institution | 456.784 | 0,60% | US$ 2,94M | 2025-08-25 |
| S & G Foundation | Institution | 435.749 | 0,57% | US$ 2,81M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 415.938 | 0,54% | US$ 2,68M | 2026-03-31 |
| FMR LLC | Institution | 392.500 | 0,51% | US$ 2,53M | 2026-03-31 |
| TD Asset Management, Inc. | Institution | 382.648 | 0,50% | US$ 2,46M | 2026-03-31 |
| Redmile Capital Offshore Fund II, Ltd | Institution | 374.149 | 0,49% | US$ 2,41M | 2025-08-25 |
| Vanguard Fiduciary Trust Company | Institution | 324.588 | 0,42% | US$ 2,09M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 316.012 | 0,41% | US$ 2,04M | 2026-03-31 |
| Redmile Strategic Long Only Trading Sub, Ltd. | Institution | 301.022 | 0,39% | US$ 1,94M | 2025-08-25 |
| Diadema Partners LP | Institution | 293.664 | 0,38% | US$ 1,89M | 2026-03-31 |