| RA Capital Management, L.P. | Institution | 10.860.977 | 10,94% | US$ 87,11M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 9.958.073 | 10,03% | US$ 79,86M | 2025-09-29 |
| OrbiMed Advisors LLC | Institution | 8.288.510 | 8,35% | US$ 66,47M | 2026-03-31 |
| OrbiMed Private Investments VI, LP | Institution | 8.019.187 | 8,08% | US$ 64,31M | 2026-03-31 |
| Rubric Capital Management LP | Institution | 8.000.000 | 8,06% | US$ 64,16M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 7.503.812 | 7,56% | US$ 60,18M | 2026-03-31 |
| Millennium Management LLC | Institution | 5.982.919 | 6,02% | US$ 47,98M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 5.194.497 | 5,23% | US$ 41,66M | 2026-03-27 |
| SR One Capital Management, LP | Institution | 4.012.903 | 4,04% | US$ 32,18M | 2026-03-31 |
| Deerfield Private Design Fund IV, L.P. | Institution | 3.805.109 | 3,83% | US$ 30,52M | 2025-07-30 |
| Deerfield Private Design Fund III, L.P. | Institution | 3.805.108 | 3,83% | US$ 30,52M | 2025-07-30 |
| Tyro Capital Management, LLC | Institution | 2.968.599 | 2,99% | US$ 23,81M | 2026-03-31 |
| Janney Montgomery Scott LLC | Institution | 2.016.464 | 2,03% | US$ 16,17M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.773.188 | 1,79% | US$ 14,22M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.361.536 | 1,37% | US$ 10,92M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 1.273.341 | 1,28% | US$ 10,21M | 2026-03-31 |
| Third Point LLC | Institution | 1.000.000 | 1,01% | US$ 8,02M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 988.624 | 1,00% | US$ 7,93M | 2025-09-30 |
| RA Capital Nexus Fund II, L.P. | Institution | 902.904 | 0,91% | US$ 7,24M | 2025-09-29 |
| General American Investors Company, Inc. | Institution | 727.154 | 0,73% | US$ 5,83M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 610.703 | 0,61% | US$ 4,90M | 2026-03-31 |
| K2 & Associates Investment Management Inc. | Institution | 559.697 | 0,56% | US$ 4,49M | 2026-03-31 |
| Levin Capital Strategies, L.P. | Institution | 552.561 | 0,56% | US$ 4,43M | 2026-03-31 |
| Empire Life Investments Inc. | Institution | 499.150 | 0,50% | US$ 4,00M | 2026-03-31 |
| Investment Management Associates, Inc. | Institution | 359.074 | 0,36% | US$ 2,88M | 2026-03-31 |
| Centerbook Partners LP | Institution | 291.179 | 0,29% | US$ 2,34M | 2026-03-31 |
| XTX Markets Limited | Institution | 276.108 | 0,28% | US$ 2,21M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 250.597 | 0,25% | US$ 2,01M | 2026-03-31 |
| Tejara Capital Limited | Institution | 210.400 | 0,21% | US$ 1,69M | 2026-03-31 |
| FAS Wealth Partners, Inc. | Institution | 205.407 | 0,21% | US$ 1,65M | 2026-03-31 |
| Landscape Capital Management, LLC | Institution | 168.789 | 0,17% | US$ 1,35M | 2026-03-31 |
| Quinn Opportunity Partners LLC | Institution | 155.000 | 0,16% | US$ 1,24M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 139.285 | 0,14% | US$ 1,12M | 2026-03-31 |