| RA Capital Management, L.P. | Institution | 10.860.977 | 10,94% | US$ 98,51M | 2026-03-31 |
| The Lowenthal-Tanimoto Family Trust | Institution | 10.106.647 | 10,18% | US$ 91,67M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 9.958.073 | 10,03% | US$ 90,32M | 2025-09-29 |
| OrbiMed Advisors LLC | Institution | 8.288.510 | 8,35% | US$ 75,18M | 2026-03-31 |
| OrbiMed Private Investments VI, LP | Institution | 8.019.187 | 8,08% | US$ 72,73M | 2026-03-31 |
| Rubric Capital Management LP | Institution | 8.000.000 | 8,06% | US$ 72,56M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 7.503.812 | 7,56% | US$ 68,06M | 2026-03-31 |
| Millennium Management LLC | Institution | 5.982.919 | 6,02% | US$ 54,27M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 5.194.497 | 5,23% | US$ 47,11M | 2026-03-27 |
| BlackRock, Inc. | Institution | 5.012.254 | 5,05% | US$ 45,46M | 2026-03-31 |
| Mr. Pratik Shah | Insider | 4.474.554 | 4,51% | US$ 40,58M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 4.113.617 | 4,14% | US$ 37,31M | 2026-03-31 |
| SR One Capital Management, LP | Institution | 4.012.903 | 4,04% | US$ 36,40M | 2026-03-31 |
| Deerfield Private Design Fund IV, L.P. | Institution | 3.805.109 | 3,83% | US$ 34,51M | 2025-07-30 |
| Deerfield Private Design Fund III, L.P. | Institution | 3.805.108 | 3,83% | US$ 34,51M | 2025-07-30 |
| State Street Global Advisors, Inc. | Institution | 3.644.966 | 3,67% | US$ 33,06M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 3.255.301 | 3,28% | US$ 29,53M | 2026-03-31 |
| Tyro Capital Management, LLC | Institution | 2.968.599 | 2,99% | US$ 26,93M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.725.006 | 2,74% | US$ 24,72M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.542.504 | 2,56% | US$ 23,06M | 2026-03-31 |
| Janney Montgomery Scott LLC | Institution | 2.016.464 | 2,03% | US$ 18,29M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.773.188 | 1,79% | US$ 16,08M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.526.824 | 1,54% | US$ 13,85M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.361.536 | 1,37% | US$ 12,35M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 1.273.341 | 1,28% | US$ 11,55M | 2026-03-31 |
| Mr. Richard Lowenthal | Insider | 1.196.494 | 1,20% | US$ 10,85M | 2026-03-31 |
| Third Point LLC | Institution | 1.000.000 | 1,01% | US$ 9,07M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 988.624 | 1,00% | US$ 8,97M | 2025-09-30 |
| RA Capital Nexus Fund II, L.P. | Institution | 902.904 | 0,91% | US$ 8,19M | 2025-09-29 |
| General American Investors Company, Inc. | Institution | 727.154 | 0,73% | US$ 6,60M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 610.703 | 0,61% | US$ 5,54M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 567.014 | 0,57% | US$ 5,14M | 2026-03-31 |
| K2 & Associates Investment Management Inc. | Institution | 559.697 | 0,56% | US$ 5,08M | 2026-03-31 |
| Levin Capital Strategies, L.P. | Institution | 552.561 | 0,56% | US$ 5,01M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 533.394 | 0,54% | US$ 4,84M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 529.284 | 0,53% | US$ 4,80M | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 525.224 | 0,53% | US$ 4,76M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 510.551 | 0,51% | US$ 4,63M | 2026-03-31 |
| Empire Life Investments Inc. | Institution | 499.150 | 0,50% | US$ 4,53M | 2026-03-31 |