| GSK Equity Investments, Limited | Institution | 9.190.606 | 15,87% | US$ 20,40M | 2026-03-31 |
| Pfizer Venture Investments LLC | Institution | 2.362.348 | 4,08% | US$ 5,24M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.799.880 | 3,11% | US$ 4,00M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.189.235 | 2,05% | US$ 2,64M | 2026-03-31 |
| GV Management Company, LLC | Institution | 889.979 | 1,54% | US$ 1,98M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 885.631 | 1,53% | US$ 1,97M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 519.922 | 0,90% | US$ 1,15M | 2026-03-31 |
| BlackRock, Inc. | Institution | 433.202 | 0,75% | US$ 961,71k | 2026-03-31 |
| Anson Group | Institution | 421.956 | 0,73% | US$ 936,74k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 376.458 | 0,65% | US$ 835,74k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 333.115 | 0,58% | US$ 739,52k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 278.304 | 0,48% | US$ 617,83k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 264.115 | 0,46% | US$ 586,34k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 214.751 | 0,37% | US$ 476,75k | 2026-03-31 |
| Ionic Capital Management LLC | Institution | 195.939 | 0,34% | US$ 434,98k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 194.301 | 0,34% | US$ 431,35k | 2026-03-31 |
| Marshall Wace LLP | Institution | 157.072 | 0,27% | US$ 348,70k | 2026-03-31 |
| Coutts Diversifying Alternatives Multi-Manager Fund | Institution | 125.762 | 0,22% | US$ 279,19k | 2025-12-31 |
| Northern Trust Global Investments | Institution | 120.984 | 0,21% | US$ 268,58k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 114.800 | 0,20% | US$ 254,86k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 106.345 | 0,18% | US$ 236,09k | 2026-03-31 |
| Shay Capital LLC | Institution | 70.354 | 0,12% | US$ 156,19k | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 59.668 | 0,10% | US$ 132,46k | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 45.374 | 0,08% | US$ 100,73k | 2026-03-31 |
| Quadrature Capital Limited | Institution | 40.128 | 0,07% | US$ 89,08k | 2026-03-31 |
| OMERS Administration Corporation | Institution | 39.400 | 0,07% | US$ 87,47k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 33.455 | 0,06% | US$ 74,27k | 2026-03-31 |
| Capital Asset Advisory Services, LLC | Institution | 32.548 | 0,06% | US$ 72,26k | 2026-03-31 |
| Simplex Trading, LLC | Institution | 30.304 | 0,05% | US$ 67,27k | 2026-03-31 |
| Three Seasons Wealth | Institution | 30.000 | 0,05% | US$ 66,60k | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 29.768 | 0,05% | US$ 66,08k | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 28.565 | 0,05% | US$ 63,41k | 2026-03-31 |
| Vanguard Global Advisers, LLC | Institution | 25.446 | 0,04% | US$ 56,49k | 2026-03-31 |