| TCG Crossover Management, LLC | Institution | 3.033.560 | 6,42% | US$ 29,91M | 2026-03-31 |
| Artal Group S.A. | Institution | 2.911.438 | 6,16% | US$ 28,71M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.164.777 | 4,58% | US$ 21,34M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 2.146.731 | 4,55% | US$ 21,17M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.234.807 | 2,61% | US$ 12,18M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.074.191 | 2,27% | US$ 10,59M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.020.489 | 2,16% | US$ 10,06M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 952.400 | 2,02% | US$ 9,39M | 2026-03-31 |
| Tetragon Partners UK LLP | Institution | 630.161 | 1,33% | US$ 6,21M | 2026-03-31 |
| Sarossa Plc | Institution | 605.174 | 1,28% | US$ 5,97M | 2025-08-01 |
| 5AM Venture Management, LLC | Institution | 476.200 | 1,01% | US$ 4,70M | 2026-03-31 |
| Schroder Unit Trusts Limited | Institution | 443.403 | 0,94% | US$ 4,37M | 2025-08-31 |
| Jones Hill Capital LP | Institution | 301.604 | 0,64% | US$ 2,97M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 286.698 | 0,61% | US$ 2,83M | 2026-03-31 |
| UBS Asset Management AG | Institution | 246.937 | 0,52% | US$ 2,43M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 209.088 | 0,44% | US$ 2,06M | 2026-03-31 |
| BlackRock, Inc. | Institution | 204.777 | 0,43% | US$ 2,02M | 2026-03-31 |
| BMO Asset Management Corp. | Institution | 202.901 | 0,43% | US$ 2,00M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 172.157 | 0,36% | US$ 1,70M | 2026-03-31 |
| Marshall Wace LLP | Institution | 169.616 | 0,36% | US$ 1,67M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 156.759 | 0,33% | US$ 1,55M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 147.668 | 0,31% | US$ 1,46M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 140.500 | 0,30% | US$ 1,39M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 135.961 | 0,29% | US$ 1,34M | 2025-12-31 |
| HSBC Global Asset Management (UK) Limited | Institution | 122.834 | 0,26% | US$ 1,21M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 119.711 | 0,25% | US$ 1,18M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 115.281 | 0,24% | US$ 1,14M | 2026-03-31 |
| XTX Markets Limited | Institution | 106.002 | 0,22% | US$ 1,05M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 104.555 | 0,22% | US$ 1,03M | 2026-03-31 |
| M28 Capital Management LP | Institution | 101.203 | 0,21% | US$ 997,86k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 100.927 | 0,21% | US$ 995,14k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 89.469 | 0,19% | US$ 882,16k | 2026-03-31 |
| Morgan Stanley | Institution | 65.486 | 0,14% | US$ 645,69k | 2026-03-31 |
| BelleCapital A.G | Institution | 58.645 | 0,12% | US$ 578,24k | 2025-06-30 |
| The Goldman Sachs Group, Inc. | Institution | 52.511 | 0,11% | US$ 517,76k | 2026-03-31 |
| Bank of America Corporation | Institution | 29.773 | 0,06% | US$ 293,56k | 2026-03-31 |
| FMR LLC | Institution | 29.538 | 0,06% | US$ 291,24k | 2026-04-30 |
| Geode Capital Management, LLC | Institution | 29.538 | 0,06% | US$ 291,24k | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 25.000 | 0,05% | US$ 246,50k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 16.203 | 0,03% | US$ 159,76k | 2026-03-31 |
| Rhumbline Advisers Ltd Partnership | Institution | 13.935 | 0,03% | US$ 137,40k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 11.994 | 0,03% | US$ 118,26k | 2026-03-31 |
| Dynamic Technology Lab Pte Ltd | Institution | 10.490 | 0,02% | US$ 103,43k | 2026-03-31 |