| Mr. Richard Griffiths | Insider | 11.220.687 | 23,76% | US$ 75,85M | 2025-08-01 |
| Mr. Robert Keith | Insider | 4.096.766 | 8,67% | US$ 27,69M | 2025-03-31 |
| TCG Crossover Management, LLC | Institution | 3.033.560 | 6,42% | US$ 20,51M | 2026-03-31 |
| Artal Group S.A. | Institution | 2.911.438 | 6,16% | US$ 19,68M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 2.479.619 | 5,25% | US$ 16,76M | 2024-09-30 |
| Redmile Group, LLC | Institution | 2.164.777 | 4,58% | US$ 14,63M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 2.146.731 | 4,55% | US$ 14,51M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.234.807 | 2,61% | US$ 8,35M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.074.191 | 2,27% | US$ 7,26M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.020.489 | 2,16% | US$ 6,90M | 2026-03-31 |
| Mr. David Kroin | Insider | 1.001.373 | 2,12% | US$ 6,77M | 2024-09-30 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 1.000.000 | 2,12% | US$ 6,76M | 2024-09-30 |
| Nextech Invest Ltd. | Institution | 952.400 | 2,02% | US$ 6,44M | 2026-03-31 |
| Tetragon Partners UK LLP | Institution | 630.161 | 1,33% | US$ 4,26M | 2026-03-31 |
| Sarossa Plc | Institution | 605.174 | 1,28% | US$ 4,09M | 2025-08-01 |
| 5AM Venture Management, LLC | Institution | 476.200 | 1,01% | US$ 3,22M | 2026-03-31 |
| Schroder Investment Management Limited | Institution | 443.403 | 0,94% | US$ 3,00M | 2025-08-31 |
| Avicenna Life Sci Master Fund Lp | Institution | 352.151 | 0,75% | US$ 2,38M | 2024-09-30 |
| Jones Hill Capital LP | Institution | 301.604 | 0,64% | US$ 2,04M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 286.698 | 0,61% | US$ 1,94M | 2026-03-31 |
| UBS Asset Management AG | Institution | 246.937 | 0,52% | US$ 1,67M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 209.088 | 0,44% | US$ 1,41M | 2026-03-31 |
| BlackRock, Inc. | Institution | 204.777 | 0,43% | US$ 1,38M | 2026-03-31 |
| BMO Asset Management Corp. | Institution | 202.901 | 0,43% | US$ 1,37M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 172.157 | 0,36% | US$ 1,16M | 2026-03-31 |
| Marshall Wace LLP | Institution | 169.616 | 0,36% | US$ 1,15M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 156.759 | 0,33% | US$ 1,06M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 147.668 | 0,31% | US$ 998,24k | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 140.500 | 0,30% | US$ 949,78k | 2026-03-31 |
| Medical Strategy GmbH | Institution | 135.961 | 0,29% | US$ 919,10k | 2025-12-31 |
| HSBC Global Asset Management (UK) Limited | Institution | 122.834 | 0,26% | US$ 830,36k | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 119.711 | 0,25% | US$ 809,25k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 115.281 | 0,24% | US$ 779,30k | 2026-03-31 |
| XTX Markets Limited | Institution | 106.002 | 0,22% | US$ 716,57k | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 104.555 | 0,22% | US$ 706,79k | 2026-03-31 |
| M28 Capital Management LP | Institution | 101.203 | 0,21% | US$ 684,13k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 100.927 | 0,21% | US$ 682,27k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 89.469 | 0,19% | US$ 604,81k | 2026-03-31 |
| Morgan Stanley | Institution | 65.486 | 0,14% | US$ 442,69k | 2026-03-31 |
| BelleCapital A.G | Institution | 58.645 | 0,12% | US$ 396,44k | 2025-06-30 |
| The Goldman Sachs Group, Inc. | Institution | 52.511 | 0,11% | US$ 354,97k | 2026-03-31 |
| Bank of America Corporation | Institution | 29.773 | 0,06% | US$ 201,27k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 29.538 | 0,06% | US$ 199,68k | 2026-03-31 |
| FMR LLC | Institution | 29.537 | 0,06% | US$ 199,67k | 2026-03-31 |