| Perceptive Advisors LLC | Institution | 11.906.646 | 12,09% | US$ 105,49M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 11.833.539 | 12,02% | US$ 104,85M | 2026-03-09 |
| Bain Capital Life Sciences Investors, LLC | Institution | 9.808.819 | 9,96% | US$ 86,91M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 9.339.978 | 9,49% | US$ 82,75M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 8.828.224 | 8,97% | US$ 78,22M | 2026-03-17 |
| Artal Group S.A. | Institution | 7.690.405 | 7,81% | US$ 68,14M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 5.825.000 | 5,92% | US$ 51,61M | 2025-02-18 |
| Vestal Point Capital, LP | Institution | 5.000.000 | 5,08% | US$ 44,30M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.958.354 | 5,04% | US$ 43,93M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 4.875.243 | 4,95% | US$ 43,19M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 4.010.695 | 4,07% | US$ 35,53M | 2026-03-31 |
| FMR LLC | Institution | 3.606.404 | 3,66% | US$ 31,95M | 2026-03-31 |
| Bain Capital Life Sciences Fund II, L.P. | Institution | 3.601.762 | 3,66% | US$ 31,91M | 2026-03-06 |
| Deep Track Capital, LP | Institution | 3.565.062 | 3,62% | US$ 31,59M | 2026-03-31 |
| Vestal Point Master Fund, LP | Institution | 3.461.165 | 3,52% | US$ 30,67M | 2026-03-31 |
| Armistice Capital LLC | Institution | 3.200.000 | 3,25% | US$ 28,35M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.674.624 | 2,72% | US$ 23,70M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.596.800 | 2,64% | US$ 23,01M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 2.438.849 | 2,48% | US$ 21,61M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 2.280.125 | 2,32% | US$ 20,20M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.192.630 | 2,23% | US$ 19,43M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 2.050.843 | 2,08% | US$ 18,17M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.011.895 | 2,04% | US$ 17,83M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 1.756.506 | 1,78% | US$ 15,56M | 2026-03-31 |
| Monashee Investment Management, LLC | Institution | 1.420.295 | 1,44% | US$ 12,58M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 1.400.000 | 1,42% | US$ 12,40M | 2025-12-31 |
| Geode Capital Management, LLC | Institution | 1.295.984 | 1,32% | US$ 11,48M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.165.078 | 1,18% | US$ 10,32M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.125.487 | 1,14% | US$ 9,97M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 956.135 | 0,97% | US$ 8,47M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 870.424 | 0,88% | US$ 7,71M | 2026-03-31 |
| Ally Bridge Group | Institution | 766.974 | 0,78% | US$ 6,80M | 2026-03-31 |
| William Blair Investment Management, LLC | Institution | 651.216 | 0,66% | US$ 5,77M | 2026-03-31 |
| Birchview Capital, LP | Institution | 625.980 | 0,64% | US$ 5,55M | 2026-03-31 |
| Woodline Partners LP | Institution | 495.076 | 0,50% | US$ 4,39M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 467.302 | 0,47% | US$ 4,14M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 418.199 | 0,42% | US$ 3,71M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 387.214 | 0,39% | US$ 3,43M | 2026-03-31 |