| Baker Bros. Advisors LP | Institution | 6.465.929 | 16,51% | US$ 11,64M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 5.966.584 | 15,24% | US$ 10,74M | 2025-02-12 |
| Whetstone Capital Advisors, LLC | Institution | 3.306.889 | 8,44% | US$ 5,95M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 2.550.775 | 6,51% | US$ 4,59M | 2026-03-31 |
| PSP Research LLC | Institution | 2.396.685 | 6,12% | US$ 4,31M | 2026-03-31 |
| Chione Ltd | Institution | 2.396.685 | 6,12% | US$ 4,31M | 2025-02-12 |
| Anthem Insurance Companies, Inc. | Institution | 2.201.974 | 5,62% | US$ 3,96M | 2025-03-31 |
| aMoon Ventures Y.SH. Ltd | Institution | 1.911.332 | 4,88% | US$ 3,44M | 2025-03-31 |
| aMoon Growth Fund II, L.P. | Institution | 1.911.332 | 4,88% | US$ 3,44M | 2025-03-31 |
| Vivo Capital, LLC | Institution | 1.650.440 | 4,21% | US$ 2,97M | 2026-03-31 |
| Vivo Capital Fund IX | Institution | 1.650.440 | 4,21% | US$ 2,97M | 2025-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.204.115 | 3,07% | US$ 2,17M | 2026-03-31 |
| CapFinancial Partners, LLC | Institution | 536.761 | 1,37% | US$ 966,17k | 2026-03-31 |
| 667, L.P. | Institution | 499.345 | 1,28% | US$ 898,82k | 2025-02-12 |
| Geode Capital Management, LLC | Institution | 363.617 | 0,93% | US$ 654,51k | 2026-03-31 |
| Sanders Morris LLC | Institution | 314.950 | 0,80% | US$ 566,91k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 248.909 | 0,64% | US$ 448,04k | 2026-03-31 |
| AWM Investment Company Inc | Institution | 207.382 | 0,53% | US$ 373,29k | 2026-03-31 |
| BlackRock, Inc. | Institution | 196.105 | 0,50% | US$ 352,99k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 169.661 | 0,43% | US$ 305,39k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 124.792 | 0,32% | US$ 224,63k | 2026-03-31 |
| Morgan Stanley | Institution | 105.017 | 0,27% | US$ 189,03k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 104.973 | 0,27% | US$ 188,95k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 96.535 | 0,25% | US$ 173,76k | 2026-03-31 |
| Millennium Management LLC | Institution | 91.504 | 0,23% | US$ 164,71k | 2026-03-31 |
| Perigon Wealth Management, LLC | Institution | 72.685 | 0,19% | US$ 130,83k | 2026-03-31 |
| BNY Asset Management | Institution | 60.927 | 0,16% | US$ 109,67k | 2026-03-31 |
| Requisite Capital Management LLC | Institution | 55.648 | 0,14% | US$ 100,17k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 53.908 | 0,14% | US$ 97,03k | 2026-03-31 |
| Ballentine Partners, LLC | Institution | 49.664 | 0,13% | US$ 89,40k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 45.705 | 0,12% | US$ 82,27k | 2026-03-31 |
| Twelve Points Wealth Management LLC | Institution | 43.388 | 0,11% | US$ 78,10k | 2026-03-31 |
| HighTower Advisors, LLC | Institution | 42.234 | 0,11% | US$ 76,02k | 2026-03-31 |
| Barclays Bank Plc | Institution | 31.967 | 0,08% | US$ 57,54k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 31.428 | 0,08% | US$ 56,57k | 2026-03-31 |
| Birch Hill Investment Advisors LLC | Institution | 27.293 | 0,07% | US$ 49,13k | 2026-03-31 |
| Cetera Investment Advisers LLC | Institution | 25.000 | 0,06% | US$ 45,00k | 2026-03-31 |
| Catalyst Funds Management Pty Ltd | Institution | 23.564 | 0,06% | US$ 42,42k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 21.964 | 0,06% | US$ 39,54k | 2026-03-31 |