| RA Capital Management, L.P. | Institution | 6.666.837 | 9,73% | US$ 584,08M | 2026-03-31 |
| BlackRock, Inc. | Institution | 6.237.151 | 9,10% | US$ 546,44M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 5.604.483 | 8,18% | US$ 491,01M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 5.134.192 | 7,49% | US$ 449,81M | 2025-03-31 |
| PRIMECAP Management Company | Institution | 3.417.509 | 4,99% | US$ 299,41M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 3.040.718 | 4,44% | US$ 266,40M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.967.825 | 4,33% | US$ 260,01M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 2.373.795 | 3,46% | US$ 207,97M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 2.373.795 | 3,46% | US$ 207,97M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.271.851 | 3,31% | US$ 199,04M | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 1.929.123 | 2,81% | US$ 169,01M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.723.253 | 2,51% | US$ 150,97M | 2026-03-31 |
| FMR LLC | Institution | 1.689.228 | 2,46% | US$ 147,99M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.654.876 | 2,41% | US$ 144,98M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.615.586 | 2,36% | US$ 141,54M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1.506.164 | 2,20% | US$ 131,96M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.418.619 | 2,07% | US$ 124,29M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.416.269 | 2,07% | US$ 124,08M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 1.286.303 | 1,88% | US$ 112,69M | 2026-03-31 |
| Capital Research and Management Company | Institution | 1.231.153 | 1,80% | US$ 107,86M | 2026-03-31 |
| Checkpoint Capital, LLC | Institution | 1.227.200 | 1,79% | US$ 107,51M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 918.153 | 1,34% | US$ 80,44M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 910.413 | 1,33% | US$ 79,76M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 846.801 | 1,24% | US$ 74,19M | 2026-03-31 |
| UBS Asset Management AG | Institution | 773.100 | 1,13% | US$ 67,73M | 2026-03-31 |
| Woodline Partners LP | Institution | 758.891 | 1,11% | US$ 66,49M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 725.744 | 1,06% | US$ 63,58M | 2026-03-31 |
| Artal Group S.A. | Institution | 725.511 | 1,06% | US$ 63,56M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 689.748 | 1,01% | US$ 60,43M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 667.046 | 0,97% | US$ 58,44M | 2026-03-31 |
| ClearBridge Investments, LLC | Institution | 609.437 | 0,89% | US$ 53,39M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 600.000 | 0,88% | US$ 52,57M | 2026-03-31 |
| Bank of America Corporation | Institution | 590.564 | 0,86% | US$ 51,74M | 2026-03-31 |
| Putnam LLC | Institution | 571.691 | 0,83% | US$ 50,09M | 2026-03-31 |
| Morgan Stanley | Institution | 564.923 | 0,82% | US$ 49,49M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 526.459 | 0,77% | US$ 46,12M | 2026-03-31 |