| Janus Henderson Group plc | Institution | 11.063.862 | 10,55% | US$ 71,36M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 8.474.571 | 8,08% | US$ 54,66M | 2026-03-31 |
| VR Management, LLC | Institution | 6.508.433 | 6,20% | US$ 41,98M | 2026-06-02 |
| Spruce Street Capital LP | Institution | 6.262.114 | 5,97% | US$ 40,39M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 4.763.158 | 4,54% | US$ 30,72M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 4.763.158 | 4,54% | US$ 30,72M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 4.715.864 | 4,50% | US$ 30,42M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 4.645.268 | 4,43% | US$ 29,96M | 2026-06-02 |
| Marshall Wace LLP | Institution | 4.481.606 | 4,27% | US$ 28,91M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.907.265 | 3,73% | US$ 25,20M | 2026-03-31 |
| Ikarian Healthcare Master Fund, L.P. | Institution | 3.543.359 | 3,38% | US$ 22,85M | 2025-09-30 |
| Vanguard Capital Management, LLC | Institution | 3.076.570 | 2,93% | US$ 19,84M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 2.947.369 | 2,81% | US$ 19,01M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 2.688.359 | 2,56% | US$ 17,34M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 2.132.053 | 2,03% | US$ 13,75M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 1.693.738 | 1,61% | US$ 10,92M | 2026-06-02 |
| Polar Capital Holdings Plc | Institution | 1.414.621 | 1,35% | US$ 9,12M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 1.295.000 | 1,23% | US$ 8,35M | 2026-04-27 |
| Commodore Capital LP | Institution | 1.295.000 | 1,23% | US$ 8,35M | 2026-04-27 |
| BlackRock, Inc. | Institution | 1.289.550 | 1,23% | US$ 8,32M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.011.572 | 0,96% | US$ 6,52M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 965.000 | 0,92% | US$ 6,22M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 935.000 | 0,89% | US$ 6,03M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 848.683 | 0,81% | US$ 5,47M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 842.106 | 0,80% | US$ 5,43M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 842.106 | 0,80% | US$ 5,43M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 842.106 | 0,80% | US$ 5,43M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 842.106 | 0,80% | US$ 5,43M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 729.055 | 0,70% | US$ 4,70M | 2026-03-31 |
| Corient Private Wealth LLC | Institution | 719.582 | 0,69% | US$ 4,64M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 712.540 | 0,68% | US$ 4,60M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 699.039 | 0,67% | US$ 4,51M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 674.833 | 0,64% | US$ 4,35M | 2024-09-30 |
| Qube Research & Technologies Ltd | Institution | 653.333 | 0,62% | US$ 4,21M | 2026-03-31 |
| StemPoint Capital LP | Institution | 597.409 | 0,57% | US$ 3,85M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 533.258 | 0,51% | US$ 3,44M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 504.820 | 0,48% | US$ 3,26M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 451.918 | 0,43% | US$ 2,91M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 450.000 | 0,43% | US$ 2,90M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 449.811 | 0,43% | US$ 2,90M | 2026-03-31 |
| Knott Partners Management, LLC | Institution | 439.300 | 0,42% | US$ 2,83M | 2026-03-31 |
| Woodline Partners LP | Institution | 421.052 | 0,40% | US$ 2,72M | 2026-03-31 |
| Birchview Capital, LP | Institution | 409.387 | 0,39% | US$ 2,64M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 408.095 | 0,39% | US$ 2,63M | 2026-03-31 |