| SB Investment Advisers (UK) Limited | Institution | 27.904.963 | 12,80% | US$ 502,85M | 2026-03-31 |
| Commodore Capital LP | Institution | 17.000.000 | 7,80% | US$ 306,34M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 14.418.574 | 6,62% | US$ 259,82M | 2026-03-31 |
| BlackRock, Inc. | Institution | 12.975.299 | 5,95% | US$ 233,81M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 9.694.217 | 4,45% | US$ 174,69M | 2025-03-19 |
| Bellevue Asset Management AG | Institution | 7.795.242 | 3,58% | US$ 140,47M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 7.387.465 | 3,39% | US$ 133,12M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.233.545 | 2,86% | US$ 112,33M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 5.526.506 | 2,54% | US$ 99,59M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 4.273.356 | 1,96% | US$ 77,01M | 2026-03-31 |
| FMR LLC | Institution | 3.691.146 | 1,69% | US$ 66,51M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.510.636 | 1,61% | US$ 63,26M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 3.039.179 | 1,39% | US$ 54,77M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 2.984.125 | 1,37% | US$ 53,77M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 2.940.536 | 1,35% | US$ 52,99M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 2.590.000 | 1,19% | US$ 46,67M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 2.359.586 | 1,08% | US$ 42,52M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.924.938 | 0,88% | US$ 34,69M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 1.904.762 | 0,87% | US$ 34,32M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.863.565 | 0,86% | US$ 33,58M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.766.685 | 0,81% | US$ 31,84M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.675.387 | 0,77% | US$ 30,19M | 2026-03-31 |
| GV Management Company, LLC | Institution | 1.564.173 | 0,72% | US$ 28,19M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.427.348 | 0,65% | US$ 25,72M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 1.424.259 | 0,65% | US$ 25,67M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.369.149 | 0,63% | US$ 24,67M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 1.254.839 | 0,58% | US$ 22,61M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1.160.117 | 0,53% | US$ 20,91M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 1.114.513 | 0,51% | US$ 20,08M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.111.891 | 0,51% | US$ 20,04M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 1.000.000 | 0,46% | US$ 18,02M | 2026-03-31 |
| Marshall Wace LLP | Institution | 941.825 | 0,43% | US$ 16,97M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 901.457 | 0,41% | US$ 16,24M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 900.546 | 0,41% | US$ 16,23M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 837.417 | 0,38% | US$ 15,09M | 2025-12-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 837.038 | 0,38% | US$ 15,08M | 2026-03-31 |
| PanAgora Asset Management, Inc. | Institution | 818.041 | 0,38% | US$ 14,74M | 2026-03-31 |