| OrbiMed Advisors LLC | Institution | 19.404.757 | 19,29% | US$ 79,17M | 2026-04-24 |
| OrbiMed Private Investments VI, LP | Institution | 17.405.831 | 17,31% | US$ 71,02M | 2026-04-24 |
| Baker Bros. Advisors LP | Institution | 17.293.897 | 17,19% | US$ 70,56M | 2026-04-21 |
| Baker Brothers Life Sciences, L.P. | Institution | 15.787.178 | 15,70% | US$ 64,41M | 2026-04-21 |
| RA Capital Management, L.P. | Institution | 6.475.882 | 6,44% | US$ 26,42M | 2026-04-27 |
| RA Capital Healthcare Fund, L.P. | Institution | 6.475.882 | 6,44% | US$ 26,42M | 2026-04-27 |
| Incyte Corporation | Institution | 4.372.124 | 4,35% | US$ 17,84M | 2025-11-03 |
| Dr. Krishna Vaddi | Insider | 3.117.278 | 3,10% | US$ 12,72M | 2025-12-31 |
| Kynam Capital Management, LP | Institution | 1.592.551 | 1,58% | US$ 6,50M | 2026-03-31 |
| 667, L.P. | Institution | 1.501.531 | 1,49% | US$ 6,13M | 2026-04-21 |
| Vanguard Capital Management, LLC | Institution | 1.230.406 | 1,22% | US$ 5,02M | 2026-03-31 |
| OrbiMed Genesis Master Fund, L.P. | Institution | 1.126.126 | 1,12% | US$ 4,59M | 2026-04-24 |
| EcoR1 Capital, LLC | Institution | 947.049 | 0,94% | US$ 3,86M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 923.626 | 0,92% | US$ 3,77M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 558.339 | 0,56% | US$ 2,28M | 2026-03-31 |
| Blue Sky Trust | Institution | 551.776 | 0,55% | US$ 2,25M | 2025-12-31 |
| OrbiMed Partners Master Fund Limited | Institution | 526.300 | 0,52% | US$ 2,15M | 2026-04-24 |
| Acadian Asset Management LLC | Institution | 511.519 | 0,51% | US$ 2,09M | 2026-03-31 |
| Dr. Paul Friedman | Insider | 500.098 | 0,50% | US$ 2,04M | 2025-03-31 |
| Dr. Andrew Combs | Insider | 480.123 | 0,48% | US$ 1,96M | 2025-03-31 |
| Millennium Management LLC | Institution | 382.737 | 0,38% | US$ 1,56M | 2026-03-31 |
| Marshall Wace LLP | Institution | 358.906 | 0,36% | US$ 1,46M | 2026-03-31 |
| Morgan Stanley | Institution | 322.161 | 0,32% | US$ 1,31M | 2026-03-31 |
| BlackRock, Inc. | Institution | 321.886 | 0,32% | US$ 1,31M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 302.458 | 0,30% | US$ 1,23M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 275.200 | 0,27% | US$ 1,12M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 267.788 | 0,27% | US$ 1,09M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 236.469 | 0,24% | US$ 964,79k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 192.963 | 0,19% | US$ 787,29k | 2026-03-31 |
| Dr. Peggy Scherle | Insider | 185.685 | 0,18% | US$ 757,59k | 2025-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 157.380 | 0,16% | US$ 642,11k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 152.825 | 0,15% | US$ 623,53k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 138.231 | 0,14% | US$ 563,98k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 124.378 | 0,12% | US$ 507,46k | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 109.085 | 0,11% | US$ 445,07k | 2026-03-31 |
| Mr. Sean Brusky | Insider | 100.000 | 0,10% | US$ 408,00k | 2026-03-05 |
| SEI Investments Company | Institution | 95.100 | 0,09% | US$ 388,01k | 2026-04-30 |
| Dr. Edna Huang | Insider | 86.917 | 0,09% | US$ 354,62k | 2025-10-04 |
| UBS Asset Management AG | Institution | 64.505 | 0,06% | US$ 263,18k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 58.699 | 0,06% | US$ 239,49k | 2026-03-31 |
| XTX Markets Limited | Institution | 57.190 | 0,06% | US$ 233,34k | 2026-03-31 |
| Bank of America Corporation | Institution | 56.525 | 0,06% | US$ 230,62k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 53.500 | 0,05% | US$ 218,28k | 2026-03-31 |