| OrbiMed Advisors LLC | Institution | 19.404.757 | 19,57% | US$ 79,56M | 2026-04-24 |
| OrbiMed Private Investments VI, LP | Institution | 17.405.831 | 17,55% | US$ 71,36M | 2026-04-24 |
| Baker Bros. Advisors LP | Institution | 17.293.897 | 17,44% | US$ 70,90M | 2026-04-21 |
| Baker Brothers Life Sciences, L.P. | Institution | 15.787.178 | 15,92% | US$ 64,73M | 2026-04-21 |
| RA Capital Management, L.P. | Institution | 6.475.882 | 6,53% | US$ 26,55M | 2026-04-27 |
| RA Capital Healthcare Fund, L.P. | Institution | 6.475.882 | 6,53% | US$ 26,55M | 2026-04-27 |
| Incyte Corporation | Institution | 4.372.124 | 4,41% | US$ 17,93M | 2025-11-03 |
| Dr. Krishna Vaddi | Insider | 3.117.278 | 3,14% | US$ 12,78M | 2025-12-31 |
| Kynam Capital Management, LP | Institution | 1.592.551 | 1,61% | US$ 6,53M | 2026-03-31 |
| 667, L.P. | Institution | 1.501.531 | 1,51% | US$ 6,16M | 2026-04-21 |
| Vanguard Capital Management, LLC | Institution | 1.230.406 | 1,24% | US$ 5,04M | 2026-03-31 |
| OrbiMed Genesis Master Fund, L.P. | Institution | 1.126.126 | 1,14% | US$ 4,62M | 2026-04-24 |
| EcoR1 Capital, LLC | Institution | 947.049 | 0,95% | US$ 3,88M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 923.626 | 0,93% | US$ 3,79M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 558.339 | 0,56% | US$ 2,29M | 2026-03-31 |
| Blue Sky Trust | Institution | 551.776 | 0,56% | US$ 2,26M | 2025-12-31 |
| OrbiMed Partners Master Fund Limited | Institution | 526.300 | 0,53% | US$ 2,16M | 2026-04-24 |
| Acadian Asset Management LLC | Institution | 511.519 | 0,52% | US$ 2,10M | 2026-03-31 |
| Dr. Paul Friedman | Insider | 500.098 | 0,50% | US$ 2,05M | 2025-03-31 |
| Dr. Andrew Combs | Insider | 480.123 | 0,48% | US$ 1,97M | 2025-03-31 |
| Millennium Management LLC | Institution | 382.737 | 0,39% | US$ 1,57M | 2026-03-31 |
| Marshall Wace LLP | Institution | 358.906 | 0,36% | US$ 1,47M | 2026-03-31 |
| Morgan Stanley | Institution | 322.161 | 0,32% | US$ 1,32M | 2026-03-31 |
| BlackRock, Inc. | Institution | 321.886 | 0,32% | US$ 1,32M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 302.458 | 0,30% | US$ 1,24M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 275.200 | 0,28% | US$ 1,13M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 267.788 | 0,27% | US$ 1,10M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 236.469 | 0,24% | US$ 969,52k | 2026-03-31 |
| SEI Investments Company | Institution | 213.586 | 0,22% | US$ 875,70k | 2026-05-31 |
| Jane Street Group, LLC | Institution | 192.963 | 0,19% | US$ 791,15k | 2026-03-31 |
| Dr. Peggy Scherle | Insider | 185.685 | 0,19% | US$ 761,31k | 2025-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 157.380 | 0,16% | US$ 645,26k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 152.825 | 0,15% | US$ 626,58k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 138.231 | 0,14% | US$ 566,75k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 124.378 | 0,13% | US$ 509,95k | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 109.085 | 0,11% | US$ 447,25k | 2026-03-31 |
| Mr. Sean Brusky | Insider | 100.000 | 0,10% | US$ 410,00k | 2026-03-05 |
| Dr. Edna Huang | Insider | 86.917 | 0,09% | US$ 356,36k | 2025-10-04 |
| UBS Asset Management AG | Institution | 64.505 | 0,07% | US$ 264,47k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 58.699 | 0,06% | US$ 240,67k | 2026-03-31 |
| XTX Markets Limited | Institution | 57.190 | 0,06% | US$ 234,48k | 2026-03-31 |
| Bank of America Corporation | Institution | 56.525 | 0,06% | US$ 231,75k | 2026-03-31 |