| Janus Henderson Group plc | Institution | 3.458.863 | 12,41% | US$ 1,11B | 2026-03-31 |
| Orbis Investment Management Limited | Institution | 2.468.413 | 8,85% | US$ 788,90M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.324.929 | 8,34% | US$ 743,05M | 2026-03-31 |
| FMR LLC | Institution | 2.160.042 | 7,75% | US$ 690,35M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 2.035.986 | 7,30% | US$ 650,70M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1.753.198 | 6,29% | US$ 560,32M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 1.622.127 | 5,82% | US$ 518,43M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 1.362.503 | 4,89% | US$ 435,46M | 2025-07-15 |
| Vanguard Capital Management, LLC | Institution | 1.221.944 | 4,38% | US$ 390,53M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 1.122.115 | 4,02% | US$ 358,63M | 2025-05-30 |
| Soleus Capital Master Fund, L.P. | Institution | 966.740 | 3,47% | US$ 308,97M | 2025-06-30 |
| Adage Capital Partners, L.P. | Institution | 965.313 | 3,46% | US$ 308,51M | 2025-12-31 |
| Deerfield Management Company, L.P. | Institution | 963.351 | 3,46% | US$ 307,89M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 949.225 | 3,40% | US$ 303,37M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 885.500 | 3,18% | US$ 283,01M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 884.238 | 3,17% | US$ 282,60M | 2026-03-31 |
| Morgan Stanley | Institution | 823.909 | 2,96% | US$ 263,32M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 815.739 | 2,93% | US$ 260,71M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 806.089 | 2,89% | US$ 257,63M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 756.748 | 2,71% | US$ 241,86M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 727.131 | 2,61% | US$ 232,39M | 2025-03-31 |
| Geode Capital Management, LLC | Institution | 650.904 | 2,33% | US$ 208,03M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 583.576 | 2,09% | US$ 186,51M | 2026-03-31 |
| Bank of America Corporation | Institution | 522.849 | 1,88% | US$ 167,10M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 373.787 | 1,34% | US$ 119,46M | 2026-03-31 |
| Hood River Capital Management LLC | Institution | 358.618 | 1,29% | US$ 114,61M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 338.895 | 1,22% | US$ 108,31M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 330.517 | 1,19% | US$ 105,63M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 286.644 | 1,03% | US$ 91,61M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 285.000 | 1,02% | US$ 91,09M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 274.623 | 0,99% | US$ 87,77M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 238.957 | 0,86% | US$ 76,37M | 2025-03-31 |
| Northern Trust Global Investments | Institution | 227.934 | 0,82% | US$ 72,85M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 215.447 | 0,77% | US$ 68,86M | 2026-03-31 |
| Woodline Partners LP | Institution | 200.013 | 0,72% | US$ 63,92M | 2026-03-31 |