| Eventide Asset Management, LLC | Institution | 12.773.577 | 6,84% | US$ 31,68M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 10.714.000 | 5,74% | US$ 26,57M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 10.714.000 | 5,74% | US$ 26,57M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 10.714.000 | 5,74% | US$ 26,57M | 2025-12-11 |
| Affinity Healthcare Fund, LP | Institution | 10.636.318 | 5,70% | US$ 26,38M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 10.636.318 | 5,70% | US$ 26,38M | 2026-03-31 |
| Sirenia Capital Management LP | Institution | 9.479.000 | 5,08% | US$ 23,51M | 2026-03-31 |
| Takeda Pharmaceutical Company Limited | Institution | 8.781.996 | 4,71% | US$ 21,78M | 2025-12-08 |
| Adage Capital Management, L.P. | Institution | 6.163.781 | 3,30% | US$ 15,29M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 5.533.073 | 2,96% | US$ 13,72M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 5.258.246 | 2,82% | US$ 13,04M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 4.544.113 | 2,43% | US$ 11,27M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 4.166.666 | 2,23% | US$ 10,33M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 3.810.543 | 2,04% | US$ 9,45M | 2026-01-02 |
| Dr. Jeremy Levin | Insider | 3.770.509 | 2,02% | US$ 9,35M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 3.571.000 | 1,91% | US$ 8,86M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 2.894.704 | 1,55% | US$ 7,18M | 2026-03-31 |
| Madison Avenue International LP | Institution | 2.852.352 | 1,53% | US$ 7,07M | 2025-02-14 |
| Ally Bridge Group | Institution | 2.818.459 | 1,51% | US$ 6,99M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.947.594 | 1,04% | US$ 4,83M | 2026-03-31 |
| CHI Advisors LLC | Institution | 1.904.666 | 1,02% | US$ 4,72M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 1.622.828 | 0,87% | US$ 4,02M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.533.283 | 0,82% | US$ 3,80M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.496.518 | 0,80% | US$ 3,71M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.320.610 | 0,71% | US$ 3,28M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.318.091 | 0,71% | US$ 3,27M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.256.869 | 0,67% | US$ 3,12M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 1.252.381 | 0,67% | US$ 3,11M | 2026-03-31 |
| Rosalind Advisors, Inc. | Institution | 1.107.994 | 0,59% | US$ 2,75M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.104.300 | 0,59% | US$ 2,74M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1.000.000 | 0,54% | US$ 2,48M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 927.913 | 0,50% | US$ 2,30M | 2026-03-31 |
| Marshall Wace LLP | Institution | 917.733 | 0,49% | US$ 2,28M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 790.644 | 0,42% | US$ 1,96M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 735.429 | 0,39% | US$ 1,82M | 2026-03-31 |
| Wells Fargo & Company | Institution | 713.625 | 0,38% | US$ 1,77M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 693.256 | 0,37% | US$ 1,72M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 520.283 | 0,28% | US$ 1,29M | 2026-03-31 |
| Walleye Capital LLC | Institution | 443.362 | 0,24% | US$ 1,10M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 367.902 | 0,20% | US$ 912,40k | 2026-03-31 |
| SEI Investments Company | Institution | 328.924 | 0,18% | US$ 815,73k | 2026-03-31 |
| Bank of America Corporation | Institution | 290.432 | 0,16% | US$ 720,27k | 2026-03-31 |
| UBS Asset Management AG | Institution | 277.656 | 0,15% | US$ 688,59k | 2026-03-31 |