| FMR LLC | Institution | 32.653.341 | 14,91% | US$ 344,17M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 19.686.282 | 8,99% | US$ 207,49M | 2026-03-31 |
| BlackRock, Inc. | Institution | 16.132.931 | 7,37% | US$ 170,04M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 12.315.000 | 5,62% | US$ 129,80M | 2026-03-31 |
| Summer Road LLC | Institution | 11.879.825 | 5,43% | US$ 125,21M | 2026-03-31 |
| VR Management, LLC | Institution | 10.346.926 | 4,73% | US$ 109,06M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 10.070.414 | 4,60% | US$ 106,14M | 2026-02-05 |
| Vanguard Capital Management, LLC | Institution | 8.719.039 | 3,98% | US$ 91,90M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 5.897.149 | 2,69% | US$ 62,16M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 5.708.637 | 2,61% | US$ 60,17M | 2025-12-31 |
| Point72 Asset Management, L.P. | Institution | 5.534.985 | 2,53% | US$ 58,34M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 4.708.419 | 2,15% | US$ 49,63M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 4.529.185 | 2,07% | US$ 47,74M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 4.129.687 | 1,89% | US$ 43,53M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 3.850.000 | 1,76% | US$ 40,58M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 3.166.600 | 1,45% | US$ 33,38M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 2.692.622 | 1,23% | US$ 28,38M | 2026-03-31 |
| Commodore Capital LP | Institution | 2.575.000 | 1,18% | US$ 27,14M | 2026-03-31 |
| Deltec Asset Management LLC | Institution | 2.340.620 | 1,07% | US$ 24,67M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.830.159 | 0,84% | US$ 19,29M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.829.537 | 0,84% | US$ 19,28M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.667.609 | 0,76% | US$ 17,58M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1.647.752 | 0,75% | US$ 17,37M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.594.666 | 0,73% | US$ 16,81M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.525.626 | 0,70% | US$ 16,08M | 2026-03-31 |
| Defilade Capital Management, L.P. | Institution | 1.487.645 | 0,68% | US$ 15,68M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.461.177 | 0,67% | US$ 15,40M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 1.429.591 | 0,65% | US$ 15,07M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.245.024 | 0,57% | US$ 13,12M | 2026-03-31 |
| Morgan Stanley | Institution | 1.188.317 | 0,54% | US$ 12,52M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.147.982 | 0,52% | US$ 12,10M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 1.049.503 | 0,48% | US$ 11,06M | 2025-12-31 |
| Squarepoint OPS LLC | Institution | 980.757 | 0,45% | US$ 10,34M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 968.597 | 0,44% | US$ 10,21M | 2026-03-31 |