| BVF Partners L.P. | Institution | 2.559.595 | 7,58% | US$ 165,96M | 2026-03-31 |
| Two Seas Capital LP | Institution | 1.959.178 | 5,80% | US$ 127,03M | 2026-03-31 |
| Two Seas Global (Master) Fund Lp | Institution | 1.959.178 | 5,80% | US$ 127,03M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.365.482 | 4,04% | US$ 88,54M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 997.300 | 2,95% | US$ 64,66M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 930.741 | 2,75% | US$ 60,35M | 2026-03-31 |
| Prosight Management, LP | Institution | 735.000 | 2,18% | US$ 47,66M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 650.710 | 1,93% | US$ 42,19M | 2026-03-31 |
| Armistice Capital LLC | Institution | 578.000 | 1,71% | US$ 37,48M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 513.531 | 1,52% | US$ 33,30M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 509.546 | 1,51% | US$ 33,04M | 2026-03-31 |
| Woodline Partners LP | Institution | 415.335 | 1,23% | US$ 26,93M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 405.080 | 1,20% | US$ 26,27M | 2026-03-31 |
| Millennium Management LLC | Institution | 404.277 | 1,20% | US$ 26,21M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 390.675 | 1,16% | US$ 25,33M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 333.576 | 0,99% | US$ 21,63M | 2025-09-30 |
| Great Point Partners, LLC | Institution | 316.453 | 0,94% | US$ 20,52M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 285.000 | 0,84% | US$ 18,48M | 2026-03-31 |
| 22NW, LP | Institution | 281.115 | 0,83% | US$ 18,23M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 275.000 | 0,81% | US$ 17,83M | 2026-03-31 |
| Gilder Gagnon Howe & Co. LLC | Institution | 271.758 | 0,80% | US$ 17,62M | 2026-03-31 |
| Nearwater Capital Markets, Limited | Institution | 261.500 | 0,77% | US$ 16,96M | 2026-03-31 |
| Braidwell LP | Institution | 222.701 | 0,66% | US$ 14,44M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 210.000 | 0,62% | US$ 13,62M | 2026-03-31 |
| Bronte Capital Management Pty Ltd | Institution | 198.256 | 0,59% | US$ 12,85M | 2026-03-31 |
| Quinn Opportunity Partners LLC | Institution | 179.247 | 0,53% | US$ 11,62M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 165.178 | 0,49% | US$ 10,71M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 161.252 | 0,48% | US$ 10,46M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 153.936 | 0,46% | US$ 9,98M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 131.733 | 0,39% | US$ 8,54M | 2024-12-31 |
| Creek Drive Management Group LLC | Institution | 126.400 | 0,37% | US$ 8,20M | 2026-03-31 |
| Seven Grand Managers LLC | Institution | 125.000 | 0,37% | US$ 8,11M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 125.000 | 0,37% | US$ 8,11M | 2026-03-31 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | Institution | 122.326 | 0,36% | US$ 7,93M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 107.385 | 0,32% | US$ 6,96M | 2026-03-31 |
| Tetragon Partners UK LLP | Institution | 103.037 | 0,30% | US$ 6,68M | 2026-03-31 |
| Monashee Investment Management, LLC | Institution | 100.000 | 0,30% | US$ 6,48M | 2026-03-31 |