| BVF Partners L.P. | Institution | 2.559.595 | 7,58% | US$ 164,81M | 2026-03-31 |
| Two Seas Capital LP | Institution | 1.959.178 | 5,80% | US$ 126,15M | 2026-03-31 |
| Two Seas Global (Master) Fund Lp | Institution | 1.959.178 | 5,80% | US$ 126,15M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.365.482 | 4,04% | US$ 87,92M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.197.055 | 3,54% | US$ 77,08M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 997.300 | 2,95% | US$ 64,22M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 930.741 | 2,75% | US$ 59,93M | 2026-03-31 |
| Prosight Management, LP | Institution | 735.000 | 2,18% | US$ 47,33M | 2026-03-31 |
| BlackRock, Inc. | Institution | 692.650 | 2,05% | US$ 44,60M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 650.710 | 1,93% | US$ 41,90M | 2026-03-31 |
| Morgan Stanley | Institution | 637.935 | 1,89% | US$ 41,08M | 2026-03-31 |
| Armistice Capital LLC | Institution | 578.000 | 1,71% | US$ 37,22M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 513.531 | 1,52% | US$ 33,07M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 509.546 | 1,51% | US$ 32,81M | 2026-03-31 |
| Invesco Ltd. | Institution | 425.341 | 1,26% | US$ 27,39M | 2026-03-31 |
| Woodline Partners LP | Institution | 415.335 | 1,23% | US$ 26,74M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 405.080 | 1,20% | US$ 26,08M | 2026-03-31 |
| Millennium Management LLC | Institution | 404.277 | 1,20% | US$ 26,03M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 390.675 | 1,16% | US$ 25,16M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 333.576 | 0,99% | US$ 21,48M | 2025-09-30 |
| Great Point Partners, LLC | Institution | 316.453 | 0,94% | US$ 20,38M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 285.000 | 0,84% | US$ 18,35M | 2026-03-31 |
| 22NW, LP | Institution | 281.115 | 0,83% | US$ 18,10M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 275.000 | 0,81% | US$ 17,71M | 2026-03-31 |
| Gilder Gagnon Howe & Co. LLC | Institution | 271.758 | 0,80% | US$ 17,50M | 2026-03-31 |
| Nearwater Capital Markets, Limited | Institution | 261.500 | 0,77% | US$ 16,84M | 2026-03-31 |
| Braidwell LP | Institution | 222.701 | 0,66% | US$ 14,34M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 210.000 | 0,62% | US$ 13,52M | 2026-03-31 |
| Bronte Capital Management Pty Ltd | Institution | 198.256 | 0,59% | US$ 12,77M | 2026-03-31 |
| Quinn Opportunity Partners LLC | Institution | 179.247 | 0,53% | US$ 11,54M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 169.308 | 0,50% | US$ 10,90M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 165.178 | 0,49% | US$ 10,64M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 161.252 | 0,48% | US$ 10,38M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 153.936 | 0,46% | US$ 9,91M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 136.730 | 0,40% | US$ 8,80M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 131.733 | 0,39% | US$ 8,48M | 2024-12-31 |