| Novo Holdings A/S | Institution | 3.686.622 | 8,13% | US$ 136,74M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.250.266 | 7,17% | US$ 120,55M | 2026-03-31 |
| Forbion Capital Partners B.V. | Institution | 3.226.400 | 7,12% | US$ 119,67M | 2026-03-31 |
| Forbion Growth Opportunities Fund III Cooperatief U.A. | Institution | 3.226.400 | 7,12% | US$ 119,67M | 2025-12-31 |
| Pivotal BioVenture Partners LLC | Institution | 1.582.700 | 3,49% | US$ 58,70M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.339.731 | 2,95% | US$ 49,69M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.133.385 | 2,50% | US$ 42,04M | 2026-03-31 |
| CHI Advisors LLC | Institution | 1.005.929 | 2,22% | US$ 37,31M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 950.011 | 2,10% | US$ 35,24M | 2026-03-31 |
| Sanofi | Institution | 912.041 | 2,01% | US$ 33,83M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 861.488 | 1,90% | US$ 31,95M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 719.820 | 1,59% | US$ 26,70M | 2026-03-31 |
| Velan Capital Partners LP | Institution | 492.893 | 1,09% | US$ 18,28M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 481.201 | 1,06% | US$ 17,85M | 2026-03-31 |
| Artal Group S.A. | Institution | 450.000 | 0,99% | US$ 16,69M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 420.000 | 0,93% | US$ 15,58M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 374.909 | 0,83% | US$ 13,91M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 364.705 | 0,80% | US$ 13,53M | 2026-03-31 |
| Mr. Vishwas Setia | Insider | 356.256 | 0,79% | US$ 13,21M | 2026-05-06 |
| Dr. Erin Foff | Insider | 346.059 | 0,76% | US$ 12,84M | 2026-05-07 |
| State Street Global Advisors, Inc. | Institution | 339.116 | 0,75% | US$ 12,58M | 2026-03-31 |
| Freestone Grove Partners LP | Institution | 313.957 | 0,69% | US$ 11,64M | 2026-03-31 |
| AXA Investment Managers S.A. | Institution | 267.746 | 0,59% | US$ 9,93M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 248.294 | 0,55% | US$ 9,21M | 2026-03-31 |
| Dr. James Lillie | Insider | 242.729 | 0,54% | US$ 9,00M | 2026-05-07 |
| UBS Asset Management AG | Institution | 236.512 | 0,52% | US$ 8,77M | 2026-03-31 |
| Dr. Robert Malenka | Insider | 216.893 | 0,48% | US$ 8,04M | 2026-04-27 |
| Dr. Anatol Kreitzer | Insider | 211.190 | 0,47% | US$ 7,83M | 2026-04-27 |
| FMR LLC | Institution | 204.501 | 0,45% | US$ 7,58M | 2026-03-31 |
| Stanford Management Company | Institution | 199.231 | 0,44% | US$ 7,39M | 2026-03-31 |
| Superstring Capital Management LP | Institution | 192.139 | 0,42% | US$ 7,13M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 171.006 | 0,38% | US$ 6,34M | 2026-03-31 |
| Mr. Kristopher Hanson | Insider | 162.331 | 0,36% | US$ 6,02M | 2026-05-11 |
| Charles Schwab Investment Management, Inc. | Institution | 161.146 | 0,36% | US$ 5,98M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 146.172 | 0,32% | US$ 5,42M | 2026-03-31 |
| Lazard Asset Management LLC | Institution | 142.016 | 0,31% | US$ 5,27M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 131.231 | 0,29% | US$ 4,87M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 112.604 | 0,25% | US$ 4,18M | 2026-03-31 |
| Tetragon Partners UK LLP | Institution | 112.115 | 0,25% | US$ 4,16M | 2026-03-31 |