| Janus Henderson Group plc | Institution | 1.317.410 | 19,67% | US$ 125,19M | 2026-03-31 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 1.006.928 | 15,03% | US$ 95,69M | 2025-03-31 |
| RA Capital Management, L.P. | Institution | 667.207 | 9,96% | US$ 63,40M | 2026-03-31 |
| AstraZeneca PLC | Institution | 522.667 | 7,80% | US$ 49,67M | 2025-12-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 511.207 | 7,63% | US$ 48,58M | 2024-10-24 |
| Saturn V Capital Management LP | Institution | 345.626 | 5,16% | US$ 32,84M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 323.745 | 4,83% | US$ 30,77M | 2026-03-31 |
| BlackRock, Inc. | Institution | 316.567 | 4,73% | US$ 30,08M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 309.195 | 4,62% | US$ 29,38M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 309.195 | 4,62% | US$ 29,38M | 2026-03-31 |
| Artal Group S.A. | Institution | 270.118 | 4,03% | US$ 25,67M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 264.278 | 3,95% | US$ 25,11M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 226.526 | 3,38% | US$ 21,53M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 218.463 | 3,26% | US$ 20,76M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 174.342 | 2,60% | US$ 16,57M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 173.506 | 2,59% | US$ 16,49M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 136.443 | 2,04% | US$ 12,97M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 132.103 | 1,97% | US$ 12,55M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 100.000 | 1,49% | US$ 9,50M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 99.918 | 1,49% | US$ 9,50M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 90.500 | 1,35% | US$ 8,60M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 88.355 | 1,32% | US$ 8,40M | 2026-03-31 |
| BNY Asset Management | Institution | 78.618 | 1,17% | US$ 7,47M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 65.418 | 0,98% | US$ 6,22M | 2026-03-31 |
| Walleye Capital LLC | Institution | 63.119 | 0,94% | US$ 6,00M | 2026-03-31 |
| Bank of America Corporation | Institution | 59.699 | 0,89% | US$ 5,67M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 58.436 | 0,87% | US$ 5,55M | 2026-03-31 |
| Millennium Management LLC | Institution | 52.951 | 0,79% | US$ 5,03M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 47.702 | 0,71% | US$ 4,53M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 45.987 | 0,69% | US$ 4,37M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 43.488 | 0,65% | US$ 4,13M | 2026-03-31 |
| Neuberger Berman Investment Advisers LLC | Institution | 42.434 | 0,63% | US$ 4,03M | 2026-03-31 |
| UBS Asset Management AG | Institution | 39.436 | 0,59% | US$ 3,75M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 33.156 | 0,49% | US$ 3,15M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 31.862 | 0,48% | US$ 3,03M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 29.946 | 0,45% | US$ 2,85M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 28.822 | 0,43% | US$ 2,74M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 28.447 | 0,42% | US$ 2,70M | 2026-03-31 |
| Barclays Bank Plc | Institution | 24.191 | 0,36% | US$ 2,30M | 2026-03-31 |
| Leap Investments LP | Institution | 22.808 | 0,34% | US$ 2,17M | 2026-03-31 |
| Morgan Stanley | Institution | 22.312 | 0,33% | US$ 2,12M | 2026-03-31 |