| Frazier Life Sciences Management, LP | Institution | 7.679.684 | 12,59% | US$ 882,93M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 6.945.813 | 11,39% | US$ 798,56M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.846.406 | 6,31% | US$ 442,22M | 2026-03-31 |
| Frazier Life Sciences IX, L.P. | Institution | 3.566.912 | 5,85% | US$ 410,09M | 2026-01-23 |
| Frazier Life Sciences Public Fund, L.P. | Institution | 2.514.947 | 4,12% | US$ 289,14M | 2026-01-23 |
| Vanguard Capital Management, LLC | Institution | 2.414.776 | 3,96% | US$ 277,63M | 2026-03-31 |
| FMR LLC | Institution | 1.964.807 | 3,22% | US$ 225,89M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.944.281 | 3,19% | US$ 223,53M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.717.421 | 2,82% | US$ 197,45M | 2026-03-31 |
| BVF Partners L.P. | Institution | 1.584.727 | 2,60% | US$ 182,20M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.432.083 | 2,35% | US$ 164,65M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.408.871 | 2,31% | US$ 161,98M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 1.334.809 | 2,19% | US$ 153,46M | 2026-03-31 |
| Novo Holdings A/S | Institution | 1.325.000 | 2,17% | US$ 152,34M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.260.003 | 2,07% | US$ 144,86M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.236.027 | 2,03% | US$ 142,11M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1.062.049 | 1,74% | US$ 122,10M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.052.048 | 1,73% | US$ 120,95M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 911.419 | 1,49% | US$ 104,79M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 811.294 | 1,33% | US$ 93,27M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 774.841 | 1,27% | US$ 89,08M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 772.595 | 1,27% | US$ 88,83M | 2025-09-30 |
| Capital Research and Management Company | Institution | 724.415 | 1,19% | US$ 83,29M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 710.938 | 1,17% | US$ 81,74M | 2026-03-31 |
| Bank of America Corporation | Institution | 676.624 | 1,11% | US$ 77,79M | 2026-03-31 |
| ClearBridge Investments, LLC | Institution | 671.870 | 1,10% | US$ 77,24M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 647.662 | 1,06% | US$ 74,46M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 625.000 | 1,02% | US$ 71,86M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 617.064 | 1,01% | US$ 70,94M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 610.666 | 1,00% | US$ 70,21M | 2025-09-30 |
| Renaissance Technologies LLC | Institution | 582.085 | 0,95% | US$ 66,92M | 2026-03-31 |
| BNY Asset Management | Institution | 579.179 | 0,95% | US$ 66,59M | 2026-03-31 |
| Woodline Partners LP | Institution | 567.894 | 0,93% | US$ 65,29M | 2026-03-31 |
| UBS Asset Management AG | Institution | 561.623 | 0,92% | US$ 64,57M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 547.306 | 0,90% | US$ 62,92M | 2026-03-31 |
| Frazier Life Sciences XI, L.P. | Institution | 544.954 | 0,89% | US$ 62,65M | 2026-01-23 |
| Balyasny Asset Management L.P. | Institution | 539.031 | 0,88% | US$ 61,97M | 2026-03-31 |