| Baker Bros. Advisors LP | Institution | 19.919.186 | 31,90% | US$ 715,90M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 18.358.772 | 29,40% | US$ 659,81M | 2025-12-18 |
| BlackRock, Inc. | Institution | 3.935.302 | 6,30% | US$ 141,43M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 2.908.836 | 4,66% | US$ 104,54M | 2025-08-18 |
| T. Rowe Price Group, Inc. | Institution | 2.876.294 | 4,61% | US$ 103,37M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.250.920 | 3,60% | US$ 80,90M | 2026-03-31 |
| Braidwell LP | Institution | 1.818.665 | 2,91% | US$ 65,36M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.717.076 | 2,75% | US$ 61,71M | 2026-03-31 |
| 667, L.P. | Institution | 1.560.414 | 2,50% | US$ 56,08M | 2025-12-18 |
| RTW Investments, LP | Institution | 1.487.934 | 2,38% | US$ 53,48M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.481.318 | 2,37% | US$ 53,24M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1.445.538 | 2,32% | US$ 51,95M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 1.361.000 | 2,18% | US$ 48,91M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 1.325.457 | 2,12% | US$ 47,64M | 2026-03-31 |
| ICONIQ Capital, LLC | Institution | 1.266.563 | 2,03% | US$ 45,52M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 1.265.795 | 2,03% | US$ 45,49M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.000.411 | 1,60% | US$ 35,95M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 991.930 | 1,59% | US$ 35,65M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 870.788 | 1,39% | US$ 31,30M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 726.547 | 1,16% | US$ 26,11M | 2026-03-31 |
| Stanford Management Company | Institution | 691.767 | 1,11% | US$ 24,86M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 690.322 | 1,11% | US$ 24,81M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 575.000 | 0,92% | US$ 20,67M | 2026-03-31 |
| Morgan Stanley | Institution | 480.224 | 0,77% | US$ 17,26M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 459.723 | 0,74% | US$ 16,52M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 436.329 | 0,70% | US$ 15,68M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 391.349 | 0,63% | US$ 14,07M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 380.000 | 0,61% | US$ 13,66M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 365.051 | 0,58% | US$ 13,12M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 349.803 | 0,56% | US$ 12,57M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 328.670 | 0,53% | US$ 11,81M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 315.400 | 0,51% | US$ 11,34M | 2026-03-31 |
| Bank of America Corporation | Institution | 300.356 | 0,48% | US$ 10,79M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 294.300 | 0,47% | US$ 10,58M | 2026-03-31 |
| Boone Capital Management LLC | Institution | 281.332 | 0,45% | US$ 10,11M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 276.953 | 0,44% | US$ 9,95M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 258.128 | 0,41% | US$ 9,28M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 229.955 | 0,37% | US$ 8,26M | 2026-03-31 |