| FMR LLC | Institution | 6.823.571 | 8,87% | US$ 440,33M | 2026-03-31 |
| Rubric Capital Management LP | Institution | 3.750.000 | 4,87% | US$ 241,99M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 2.876.015 | 3,74% | US$ 185,59M | 2026-05-29 |
| Baker Brothers Life Sciences, L.P. | Institution | 2.738.816 | 3,56% | US$ 176,74M | 2026-05-29 |
| Tang Capital Management, LLC | Institution | 2.259.889 | 2,94% | US$ 145,83M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.766.268 | 2,30% | US$ 113,98M | 2026-03-31 |
| Mr. Sanjiv Patel | Insider | 1.763.923 | 2,29% | US$ 113,83M | 2026-06-01 |
| Dr. Robert Desnick | Insider | 1.478.505 | 1,92% | US$ 95,41M | 2025-04-08 |
| Acadian Asset Management LLC | Institution | 1.336.313 | 1,74% | US$ 86,23M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.333.093 | 1,73% | US$ 86,02M | 2026-03-31 |
| Tang Capital Partners, LP | Institution | 1.225.272 | 1,59% | US$ 79,07M | 2025-03-28 |
| Morgan Stanley | Institution | 970.043 | 1,26% | US$ 62,60M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 959.257 | 1,25% | US$ 61,90M | 2026-03-31 |
| Tang Capital Partners International, LP | Institution | 953.337 | 1,24% | US$ 61,52M | 2025-03-28 |
| Arrowstreet Capital, Limited Partnership | Institution | 892.666 | 1,16% | US$ 57,60M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 811.922 | 1,06% | US$ 52,39M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 761.063 | 0,99% | US$ 49,11M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 686.853 | 0,89% | US$ 44,32M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 649.629 | 0,84% | US$ 41,92M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 647.731 | 0,84% | US$ 41,80M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 640.958 | 0,83% | US$ 41,36M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 640.179 | 0,83% | US$ 41,31M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 623.288 | 0,81% | US$ 40,22M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 611.398 | 0,79% | US$ 39,45M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 608.416 | 0,79% | US$ 39,26M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 598.888 | 0,78% | US$ 38,65M | 2026-03-31 |
| Millennium Management LLC | Institution | 564.420 | 0,73% | US$ 36,42M | 2026-03-31 |
| Bank of America Corporation | Institution | 557.720 | 0,72% | US$ 35,99M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 523.691 | 0,68% | US$ 33,79M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 521.353 | 0,68% | US$ 33,64M | 2026-03-31 |
| Victory Capital Management Inc. | Institution | 506.521 | 0,66% | US$ 32,69M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 499.792 | 0,65% | US$ 32,25M | 2026-03-31 |
| BlackRock, Inc. | Institution | 486.737 | 0,63% | US$ 31,41M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 481.023 | 0,63% | US$ 31,04M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 474.750 | 0,62% | US$ 30,64M | 2026-03-31 |
| Massachusetts Financial Services Company | Institution | 438.002 | 0,57% | US$ 28,26M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 428.972 | 0,56% | US$ 27,68M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 420.914 | 0,55% | US$ 27,16M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 383.811 | 0,50% | US$ 24,77M | 2026-03-31 |