| FMR LLC | Institution | 5.586.783 | 14,63% | US$ 391,97M | 2026-03-31 |
| Access Industries, Inc. | Institution | 2.814.379 | 7,37% | US$ 197,46M | 2026-04-22 |
| RA Capital Management, L.P. | Institution | 2.450.221 | 6,41% | US$ 171,91M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.273.831 | 5,95% | US$ 159,53M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 2.228.924 | 5,84% | US$ 156,38M | 2025-12-30 |
| Wellington Management Group LLP | Institution | 1.735.376 | 4,54% | US$ 121,75M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.698.244 | 4,45% | US$ 119,15M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.549.350 | 4,06% | US$ 108,70M | 2026-03-31 |
| Atlas Venture Advisors, Inc. | Institution | 1.513.875 | 3,96% | US$ 106,21M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.375.430 | 3,60% | US$ 96,50M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 1.354.852 | 3,55% | US$ 95,06M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 1.341.862 | 3,51% | US$ 94,15M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1.338.831 | 3,50% | US$ 93,93M | 2026-03-31 |
| BVF Partners L.P. | Institution | 1.272.312 | 3,33% | US$ 89,27M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 1.067.550 | 2,79% | US$ 74,90M | 2026-03-31 |
| Artal Group S.A. | Institution | 988.401 | 2,59% | US$ 69,35M | 2026-03-31 |
| Woodline Partners LP | Institution | 958.281 | 2,51% | US$ 67,23M | 2026-03-31 |
| Atlas Venture Fund X, L.P. | Institution | 813.167 | 2,13% | US$ 57,05M | 2025-12-17 |
| Orbimed Private Investments VIII, LP | Institution | 746.171 | 1,95% | US$ 52,35M | 2025-03-24 |
| Geode Capital Management, LLC | Institution | 744.222 | 1,95% | US$ 52,21M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 700.000 | 1,83% | US$ 49,11M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 657.000 | 1,72% | US$ 46,10M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 615.686 | 1,61% | US$ 43,20M | 2026-03-31 |
| Jennison Associates LLC | Institution | 610.382 | 1,60% | US$ 42,82M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 560.000 | 1,47% | US$ 39,29M | 2026-03-31 |
| Medical Strategy GmbH | Institution | 549.219 | 1,44% | US$ 38,53M | 2025-12-31 |
| Assenagon Asset Management S.A. | Institution | 546.247 | 1,43% | US$ 38,32M | 2026-03-31 |
| Armistice Capital LLC | Institution | 536.000 | 1,40% | US$ 37,61M | 2026-03-31 |
| OrbiMed Private Investments VI, LP | Institution | 482.308 | 1,26% | US$ 33,84M | 2025-03-24 |
| Bellevue Asset Management AG | Institution | 459.314 | 1,20% | US$ 32,23M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 449.926 | 1,18% | US$ 31,57M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 421.000 | 1,10% | US$ 29,54M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 401.719 | 1,05% | US$ 28,18M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 395.572 | 1,04% | US$ 27,75M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 394.447 | 1,03% | US$ 27,67M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 387.005 | 1,01% | US$ 27,15M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 375.614 | 0,98% | US$ 26,35M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 374.069 | 0,98% | US$ 26,24M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 349.657 | 0,92% | US$ 24,53M | 2026-03-31 |