| FMR LLC | Institution | 9.339.573 | 11,40% | US$ 10,09M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 4.233.529 | 5,17% | US$ 4,57M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.308.406 | 4,04% | US$ 3,57M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.901.208 | 3,54% | US$ 3,13M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 2.370.122 | 2,89% | US$ 2,56M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.212.819 | 2,70% | US$ 2,39M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.470.108 | 1,79% | US$ 1,59M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.410.845 | 1,72% | US$ 1,52M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 1.035.360 | 1,26% | US$ 1,12M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 804.958 | 0,98% | US$ 869,35k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 801.504 | 0,98% | US$ 865,62k | 2026-03-31 |
| BlackRock, Inc. | Institution | 662.181 | 0,81% | US$ 715,16k | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 643.777 | 0,79% | US$ 695,28k | 2026-03-31 |
| Diadema Partners LP | Institution | 562.665 | 0,69% | US$ 607,68k | 2026-03-31 |
| Stonepine Capital, L.P. | Institution | 518.331 | 0,63% | US$ 559,80k | 2025-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 392.066 | 0,48% | US$ 423,43k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 390.384 | 0,48% | US$ 421,61k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 298.870 | 0,36% | US$ 322,78k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 296.310 | 0,36% | US$ 320,01k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 286.352 | 0,35% | US$ 309,26k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 265.075 | 0,32% | US$ 286,28k | 2026-03-31 |
| UBS Asset Management AG | Institution | 249.650 | 0,30% | US$ 269,62k | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 248.790 | 0,30% | US$ 268,69k | 2026-03-31 |
| XTX Markets Limited | Institution | 212.677 | 0,26% | US$ 229,69k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 173.000 | 0,21% | US$ 186,84k | 2026-03-31 |
| Persistent Asset Partners Limited | Institution | 142.164 | 0,17% | US$ 153,54k | 2026-03-31 |
| GMT Capital Corp. | Institution | 126.119 | 0,15% | US$ 136,21k | 2026-03-31 |
| Dr. Jacqueline Shea | Insider | 111.021 | 0,14% | US$ 119,90k | 2026-05-20 |
| Dr. David B. Weiner | Insider | 87.592 | 0,11% | US$ 94,60k | 2026-02-26 |
| Green Alpha Advisors, LLC | Institution | 65.580 | 0,08% | US$ 70,83k | 2026-03-31 |
| Morgan Stanley | Institution | 63.793 | 0,08% | US$ 68,90k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 56.862 | 0,07% | US$ 61,41k | 2026-03-31 |
| Tower Research Capital Europe Limited | Institution | 55.491 | 0,07% | US$ 59,93k | 2026-03-31 |
| CIBC Private Wealth Advisors, Inc. | Institution | 50.000 | 0,06% | US$ 54,00k | 2026-03-31 |
| Dr. Laurent Humeau | Insider | 46.823 | 0,06% | US$ 50,57k | 2026-05-20 |
| Goldman Sachs Asset Management, L.P. | Institution | 44.724 | 0,05% | US$ 48,30k | 2026-03-31 |
| Mr. Peter Kies | Insider | 43.229 | 0,05% | US$ 46,69k | 2026-05-20 |
| Dr. Michael Sumner | Insider | 42.038 | 0,05% | US$ 45,40k | 2026-05-20 |