| Baker Bros. Advisors LP | Institution | 31.073.451 | 15,55% | US$ 3,53B | 2026-06-08 |
| Baker Brothers Life Sciences, L.P. | Institution | 28.205.360 | 14,12% | US$ 3,21B | 2026-06-08 |
| BlackRock, Inc. | Institution | 18.977.800 | 9,50% | US$ 2,16B | 2026-03-31 |
| Dodge & Cox | Institution | 12.252.356 | 6,13% | US$ 1,39B | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 7.759.183 | 3,88% | US$ 882,61M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 5.647.816 | 2,83% | US$ 642,44M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 4.703.184 | 2,35% | US$ 534,99M | 2026-03-31 |
| LSV Asset Management | Institution | 3.920.056 | 1,96% | US$ 445,91M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 3.651.532 | 1,83% | US$ 415,36M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3.266.136 | 1,63% | US$ 371,52M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 3.090.360 | 1,55% | US$ 351,53M | 2026-03-31 |
| 667, L.P. | Institution | 2.834.681 | 1,42% | US$ 322,44M | 2026-06-08 |
| Arrowstreet Capital, Limited Partnership | Institution | 2.830.799 | 1,42% | US$ 322,00M | 2026-03-31 |
| Boston Partners Global Investors, Inc. | Institution | 2.514.383 | 1,26% | US$ 286,01M | 2026-03-31 |
| Los Angeles Capital Management LLC | Institution | 2.144.847 | 1,07% | US$ 243,98M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.975.544 | 0,99% | US$ 224,72M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.900.824 | 0,95% | US$ 216,22M | 2026-03-31 |
| Victory Capital Management Inc. | Institution | 1.742.870 | 0,87% | US$ 198,25M | 2026-03-31 |
| Pacer Advisors, Inc. | Institution | 1.741.061 | 0,87% | US$ 198,05M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.729.102 | 0,87% | US$ 196,69M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 1.717.978 | 0,86% | US$ 195,42M | 2026-03-31 |
| La Caisse de dépôt et placement du Québec | Institution | 1.520.486 | 0,76% | US$ 172,96M | 2026-03-31 |
| First Trust Advisors LP | Institution | 1.500.792 | 0,75% | US$ 170,72M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 1.275.323 | 0,64% | US$ 145,07M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.253.138 | 0,63% | US$ 142,54M | 2026-03-31 |
| PanAgora Asset Management, Inc. | Institution | 1.210.909 | 0,61% | US$ 137,74M | 2026-03-31 |
| Australian Super Pty Ltd | Institution | 1.137.143 | 0,57% | US$ 129,35M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.075.898 | 0,54% | US$ 122,38M | 2026-03-31 |
| FMR LLC | Institution | 1.058.843 | 0,53% | US$ 120,44M | 2026-03-31 |
| Amundi Asset Management SAS | Institution | 1.048.733 | 0,52% | US$ 119,29M | 2026-03-31 |
| Numeric Investors LLC | Institution | 927.672 | 0,46% | US$ 105,52M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 916.188 | 0,46% | US$ 104,22M | 2026-03-31 |
| RBC Global Asset Management Inc. | Institution | 909.185 | 0,46% | US$ 103,42M | 2026-03-31 |
| Virginia Retirement System | Institution | 768.325 | 0,38% | US$ 87,40M | 2025-12-31 |
| Sound Shore Management, Inc. | Institution | 767.829 | 0,38% | US$ 87,34M | 2026-03-31 |