| Avidity Private Master Fund I LP | Institution | 1.395.841 | 10,25% | US$ 16,83M | 2026-02-17 |
| Janus Henderson Group plc | Institution | 1.201.644 | 8,82% | US$ 14,49M | 2025-11-28 |
| Aberdeen Group Plc | Institution | 824.394 | 6,05% | US$ 9,94M | 2026-03-31 |
| Millennium Management LLC | Institution | 793.621 | 5,83% | US$ 9,57M | 2026-04-29 |
| BVF Partners L.P. | Institution | 765.297 | 5,62% | US$ 9,23M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 743.281 | 5,46% | US$ 8,96M | 2026-04-29 |
| Avidity Partners Management, L.P. | Institution | 669.941 | 4,92% | US$ 8,08M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 513.831 | 3,77% | US$ 6,20M | 2026-03-31 |
| Soleus Capital Master Fund, L.P. | Institution | 450.000 | 3,30% | US$ 5,43M | 2026-02-17 |
| Soleus Capital Management, L.P. | Institution | 450.000 | 3,30% | US$ 5,43M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 413.596 | 3,04% | US$ 4,99M | 2026-02-20 |
| Laurion Capital Management LP | Institution | 388.216 | 2,85% | US$ 4,68M | 2026-03-31 |
| Morgan Stanley | Institution | 328.854 | 2,41% | US$ 3,97M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 302.711 | 2,22% | US$ 3,65M | 2026-02-20 |
| Nantahala Capital Management, LLC | Institution | 250.649 | 1,84% | US$ 3,02M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 245.000 | 1,80% | US$ 2,95M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 190.584 | 1,40% | US$ 2,30M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 152.576 | 1,12% | US$ 1,84M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 139.860 | 1,03% | US$ 1,69M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 139.860 | 1,03% | US$ 1,69M | 2025-06-30 |
| Soleus Capital LLC | Institution | 106.046 | 0,78% | US$ 1,28M | 2025-09-30 |
| Soleus Private Equity Fund III LP | Institution | 106.046 | 0,78% | US$ 1,28M | 2025-09-30 |
| Susquehanna International Group, LLP | Institution | 102.825 | 0,75% | US$ 1,24M | 2026-03-31 |
| Woodline Partners LP | Institution | 96.715 | 0,71% | US$ 1,17M | 2026-03-31 |
| BlackRock, Inc. | Institution | 96.423 | 0,71% | US$ 1,16M | 2026-03-31 |
| Marshall Wace LLP | Institution | 95.296 | 0,70% | US$ 1,15M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 91.916 | 0,67% | US$ 1,11M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 74.054 | 0,54% | US$ 893,09k | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 67.466 | 0,50% | US$ 813,64k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 65.915 | 0,48% | US$ 794,93k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 56.564 | 0,42% | US$ 682,16k | 2026-03-31 |
| UBS Asset Management AG | Institution | 52.279 | 0,38% | US$ 630,48k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 49.339 | 0,36% | US$ 595,03k | 2026-03-31 |
| Simplify Asset Management Inc. | Institution | 43.893 | 0,32% | US$ 529,35k | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 42.763 | 0,31% | US$ 515,72k | 2026-02-20 |
| Dr. Daniel Vitt | Insider | 39.188 | 0,29% | US$ 472,61k | 2025-06-04 |
| Dr. Andreas Muehler | Insider | 33.954 | 0,25% | US$ 409,49k | 2025-03-31 |
| Northern Trust Global Investments | Institution | 26.332 | 0,19% | US$ 317,56k | 2026-03-31 |
| Dr. Richard Rudick | Insider | 23.038 | 0,17% | US$ 277,84k | 2025-06-03 |
| Hudson Bay Capital Management LP | Institution | 21.301 | 0,16% | US$ 256,89k | 2026-03-31 |