| FMR LLC | Institution | 13.172.008 | 14,99% | US$ 483,94M | 2026-03-31 |
| BlackRock, Inc. | Institution | 8.442.133 | 9,61% | US$ 310,16M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 7.265.253 | 8,27% | US$ 266,93M | 2026-03-31 |
| Capital Research and Management Company | Institution | 5.163.543 | 5,88% | US$ 189,71M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.412.432 | 5,02% | US$ 162,11M | 2025-06-06 |
| Baker Bros. Advisors LP | Institution | 3.946.515 | 4,49% | US$ 144,99M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3.781.167 | 4,30% | US$ 138,92M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.732.422 | 4,25% | US$ 137,13M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 3.450.000 | 3,93% | US$ 126,75M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 2.987.107 | 3,40% | US$ 109,75M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 2.823.500 | 3,21% | US$ 103,74M | 2026-03-31 |
| Fiera Capital Corporation | Institution | 2.527.076 | 2,88% | US$ 92,84M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.500.724 | 2,85% | US$ 91,88M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 1.530.008 | 1,74% | US$ 56,21M | 2026-03-31 |
| Morgan Stanley | Institution | 1.475.386 | 1,68% | US$ 54,21M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.333.478 | 1,52% | US$ 48,99M | 2026-03-31 |
| GSK Equity Investments, Limited | Institution | 1.333.333 | 1,52% | US$ 48,99M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.315.869 | 1,50% | US$ 48,35M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 1.131.786 | 1,29% | US$ 41,58M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 1.107.708 | 1,26% | US$ 40,70M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.021.083 | 1,16% | US$ 37,51M | 2026-03-31 |
| UBS Asset Management AG | Institution | 937.699 | 1,07% | US$ 34,45M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 899.504 | 1,02% | US$ 33,05M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 882.699 | 1,00% | US$ 32,43M | 2026-03-31 |
| First Turn Management, LLC | Institution | 873.838 | 0,99% | US$ 32,10M | 2026-03-31 |
| BNPP Asset Management Holding | Institution | 814.872 | 0,93% | US$ 29,94M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 745.593 | 0,85% | US$ 27,39M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 734.121 | 0,84% | US$ 26,97M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 715.906 | 0,81% | US$ 26,30M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 715.527 | 0,81% | US$ 26,29M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 679.400 | 0,77% | US$ 24,96M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 634.534 | 0,72% | US$ 23,31M | 2026-03-31 |
| Bank of America Corporation | Institution | 632.553 | 0,72% | US$ 23,24M | 2026-03-31 |