| Janus Henderson Group plc | Institution | 5.247.151 | 10,04% | US$ 52,52M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 5.049.779 | 9,66% | US$ 50,55M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 5.049.779 | 9,66% | US$ 50,55M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.145.303 | 7,93% | US$ 41,49M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 3.784.180 | 7,24% | US$ 37,88M | 2026-03-31 |
| Novo Holdings A/S | Institution | 3.650.737 | 6,98% | US$ 36,54M | 2026-03-31 |
| BVF Partners L.P. | Institution | 2.879.289 | 5,51% | US$ 28,82M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.707.875 | 5,18% | US$ 27,11M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.195.578 | 4,20% | US$ 21,98M | 2026-03-31 |
| Armistice Capital LLC | Institution | 2.000.000 | 3,83% | US$ 20,02M | 2026-03-31 |
| Dr. David Kirn | Insider | 1.659.153 | 3,17% | US$ 16,61M | 2026-04-20 |
| Adage Capital Management, L.P. | Institution | 1.605.156 | 3,07% | US$ 16,07M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.440.287 | 2,76% | US$ 14,42M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 1.432.260 | 2,74% | US$ 14,34M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 1.302.917 | 2,49% | US$ 13,04M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 1.093.101 | 2,09% | US$ 10,94M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.065.345 | 2,04% | US$ 10,66M | 2026-03-31 |
| Hillhouse Investment Management, Ltd. | Institution | 951.474 | 1,82% | US$ 9,52M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 708.044 | 1,35% | US$ 7,09M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 609.900 | 1,17% | US$ 6,11M | 2024-12-31 |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Institution | 601.161 | 1,15% | US$ 6,02M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 578.265 | 1,11% | US$ 5,79M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 555.829 | 1,06% | US$ 5,56M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 548.991 | 1,05% | US$ 5,50M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 522.823 | 1,00% | US$ 5,23M | 2026-03-31 |
| Parkman Healthcare Partners LLC | Institution | 522.577 | 1,00% | US$ 5,23M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 490.614 | 0,94% | US$ 4,91M | 2025-03-31 |
| RTW Investments, LP | Institution | 475.737 | 0,91% | US$ 4,76M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 421.258 | 0,81% | US$ 4,22M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 381.395 | 0,73% | US$ 3,82M | 2026-03-31 |
| Bank of America Corporation | Institution | 373.012 | 0,71% | US$ 3,73M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 342.034 | 0,65% | US$ 3,42M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 328.379 | 0,63% | US$ 3,29M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 309.990 | 0,59% | US$ 3,10M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 289.025 | 0,55% | US$ 2,89M | 2026-03-31 |