| Suvretta Capital Management, LLC | Institution | 8.296.375 | 9,90% | US$ 109,47M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 8.265.000 | 9,86% | US$ 109,06M | 2026-03-31 |
| BlackRock, Inc. | Institution | 7.177.337 | 8,56% | US$ 94,70M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 5.669.589 | 6,76% | US$ 74,81M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 4.250.000 | 5,07% | US$ 56,08M | 2026-05-27 |
| Commodore Capital LP | Institution | 4.250.000 | 5,07% | US$ 56,08M | 2026-05-27 |
| Paradigm BioCapital International Fund Ltd. | Institution | 3.694.542 | 4,41% | US$ 48,75M | 2026-02-17 |
| TCG Crossover Fund II, L.P. | Institution | 3.572.335 | 4,26% | US$ 47,14M | 2024-10-31 |
| Adage Capital Management, L.P. | Institution | 3.300.000 | 3,94% | US$ 43,54M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 3.300.000 | 3,94% | US$ 43,54M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 3.181.818 | 3,80% | US$ 41,98M | 2024-12-31 |
| Paradigm Biocapital Advisors LP | Institution | 3.142.437 | 3,75% | US$ 41,46M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.097.202 | 2,50% | US$ 27,67M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.983.665 | 2,37% | US$ 26,17M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.905.875 | 2,27% | US$ 25,15M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.438.737 | 1,72% | US$ 18,98M | 2026-03-31 |
| Parkman Healthcare Partners LLC | Institution | 1.354.800 | 1,62% | US$ 17,88M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.245.583 | 1,49% | US$ 16,44M | 2026-03-31 |
| Essex Woodlands Management, Inc. | Institution | 1.084.857 | 1,29% | US$ 14,31M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 1.069.147 | 1,28% | US$ 14,11M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 1.050.000 | 1,25% | US$ 13,85M | 2026-03-31 |
| Rosalind Advisors, Inc. | Institution | 1.036.737 | 1,24% | US$ 13,68M | 2026-03-31 |
| CHI Advisors LLC | Institution | 912.594 | 1,09% | US$ 12,04M | 2026-03-31 |
| StemPoint Capital LP | Institution | 810.764 | 0,97% | US$ 10,70M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 795.000 | 0,95% | US$ 10,49M | 2026-03-31 |
| Artia Global Partners LP | Institution | 767.098 | 0,91% | US$ 10,12M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 721.785 | 0,86% | US$ 9,52M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 674.395 | 0,80% | US$ 8,90M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 551.827 | 0,66% | US$ 7,28M | 2026-03-31 |
| PrIncipia Wealth Advisory, LLC | Institution | 530.725 | 0,63% | US$ 7,00M | 2025-12-31 |
| Alyeska Investment Group, L.P. | Institution | 509.403 | 0,61% | US$ 6,72M | 2026-03-31 |
| Millennium Management LLC | Institution | 475.190 | 0,57% | US$ 6,27M | 2026-03-31 |
| ExodusPoint Capital Management, LP | Institution | 458.102 | 0,55% | US$ 6,04M | 2026-03-31 |