| OrbiMed Advisors LLC | Institution | 15.518.492 | 14,42% | US$ 630,52M | 2026-03-31 |
| OrbiMed Private Investments VI, LP | Institution | 14.809.075 | 13,76% | US$ 601,69M | 2025-05-12 |
| RA Capital Management, L.P. | Institution | 10.428.437 | 9,69% | US$ 423,71M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 7.365.038 | 6,85% | US$ 299,24M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 6.575.940 | 6,11% | US$ 267,18M | 2026-03-31 |
| BlackRock, Inc. | Institution | 6.472.991 | 6,02% | US$ 263,00M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 6.395.546 | 5,94% | US$ 259,85M | 2025-03-31 |
| Janus Henderson Group plc | Institution | 5.915.556 | 5,50% | US$ 240,35M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 5.424.167 | 5,04% | US$ 220,38M | 2024-09-30 |
| Novo Holdings A/S | Institution | 5.350.000 | 4,97% | US$ 217,37M | 2026-04-23 |
| Driehaus Capital Management LLC | Institution | 4.477.942 | 4,16% | US$ 181,94M | 2026-03-31 |
| Artal Group S.A. | Institution | 4.430.263 | 4,12% | US$ 180,00M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 4.423.974 | 4,11% | US$ 179,75M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 4.181.497 | 3,89% | US$ 169,89M | 2025-01-27 |
| Vanguard Capital Management, LLC | Institution | 3.788.161 | 3,52% | US$ 153,91M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 3.260.000 | 3,03% | US$ 132,45M | 2026-03-31 |
| Braidwell LP | Institution | 2.347.583 | 2,18% | US$ 95,38M | 2026-03-31 |
| Morgan Stanley | Institution | 2.196.230 | 2,04% | US$ 89,23M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.789.819 | 1,66% | US$ 72,72M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 1.722.169 | 1,60% | US$ 69,97M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.716.823 | 1,60% | US$ 69,75M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1.660.696 | 1,54% | US$ 67,47M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 1.600.000 | 1,49% | US$ 65,01M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 1.528.518 | 1,42% | US$ 62,10M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 1.449.915 | 1,35% | US$ 58,91M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.425.845 | 1,33% | US$ 57,93M | 2026-03-31 |
| Deerfield Private Design Fund IV, L.P. | Institution | 1.301.626 | 1,21% | US$ 52,89M | 2024-09-30 |
| Bank of America Corporation | Institution | 1.267.319 | 1,18% | US$ 51,49M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.219.717 | 1,13% | US$ 49,56M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 1.147.176 | 1,07% | US$ 46,61M | 2026-03-31 |
| New Leaf Venture Partners, LLC | Institution | 1.030.161 | 0,96% | US$ 41,86M | 2025-09-30 |
| FMR LLC | Institution | 1.017.014 | 0,95% | US$ 41,32M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 1.001.846 | 0,93% | US$ 40,71M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 826.059 | 0,77% | US$ 33,56M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 825.910 | 0,77% | US$ 33,56M | 2026-03-31 |
| Victory Capital Management Inc. | Institution | 789.043 | 0,73% | US$ 32,06M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 751.355 | 0,70% | US$ 30,53M | 2025-12-31 |
| Artisan Partners Limited Partnership | Institution | 659.067 | 0,61% | US$ 26,78M | 2026-03-31 |
| Marshall Wace LLP | Institution | 648.393 | 0,60% | US$ 26,34M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 596.310 | 0,55% | US$ 24,23M | 2026-03-31 |