| Opaleye Management Inc. | Institution | 2.860.000 | 10,44% | US$ 107,25M | 2026-03-31 |
| Opaleye L.P | Institution | 2.770.000 | 10,11% | US$ 103,88M | 2025-06-10 |
| EcoR1 Capital, LLC | Institution | 2.171.938 | 7,93% | US$ 81,45M | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 1.864.034 | 6,80% | US$ 69,90M | 2024-12-31 |
| BlackRock, Inc. | Institution | 1.717.286 | 6,27% | US$ 64,40M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.175.951 | 4,29% | US$ 44,10M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 994.089 | 3,63% | US$ 37,28M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 577.666 | 2,11% | US$ 21,66M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 530.215 | 1,94% | US$ 19,88M | 2026-03-31 |
| National Philanthropic Trust | Institution | 492.112 | 1,80% | US$ 18,45M | 2026-03-31 |
| Westside Investment Management, LLC | Institution | 467.915 | 1,71% | US$ 17,55M | 2026-03-31 |
| Morgan Stanley | Institution | 457.338 | 1,67% | US$ 17,15M | 2026-03-31 |
| Oberweis Asset Management, Inc. | Institution | 439.300 | 1,60% | US$ 16,47M | 2026-03-31 |
| Thompson, Siegel & Walmsley LLC | Institution | 406.089 | 1,48% | US$ 15,23M | 2026-03-31 |
| Pillsbury Lake Capital, LLC | Institution | 364.954 | 1,33% | US$ 13,69M | 2026-03-31 |
| Cannell Capital LLC | Institution | 341.985 | 1,25% | US$ 12,82M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 302.108 | 1,10% | US$ 11,33M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 237.832 | 0,87% | US$ 8,92M | 2026-03-31 |
| Dr. Norbert Riedel | Insider | 224.300 | 0,82% | US$ 8,41M | 2026-04-21 |
| Prelude Capital Management, LLC | Institution | 188.802 | 0,69% | US$ 7,08M | 2026-03-31 |
| Aristides Capital LLC | Institution | 186.041 | 0,68% | US$ 6,98M | 2026-03-31 |
| Panoramic Capital, Llc | Institution | 185.000 | 0,68% | US$ 6,94M | 2026-03-31 |
| Lumbard & Kellner, LLC | Institution | 175.911 | 0,64% | US$ 6,60M | 2026-03-31 |
| Woodline Partners LP | Institution | 170.699 | 0,62% | US$ 6,40M | 2026-03-31 |
| UBS Asset Management AG | Institution | 169.326 | 0,62% | US$ 6,35M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 166.381 | 0,61% | US$ 6,24M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 165.942 | 0,61% | US$ 6,22M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 165.462 | 0,60% | US$ 6,20M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 164.715 | 0,60% | US$ 6,18M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 163.321 | 0,60% | US$ 6,12M | 2026-03-31 |
| Diametric Capital, LP | Institution | 156.926 | 0,57% | US$ 5,88M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 151.748 | 0,55% | US$ 5,69M | 2026-03-31 |
| Bank of America Corporation | Institution | 144.367 | 0,53% | US$ 5,41M | 2026-03-31 |
| BNY Asset Management | Institution | 111.255 | 0,41% | US$ 4,17M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 107.815 | 0,39% | US$ 4,04M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 106.393 | 0,39% | US$ 3,99M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 95.420 | 0,35% | US$ 3,58M | 2026-03-31 |
| Marshall Wace LLP | Institution | 82.721 | 0,30% | US$ 3,10M | 2026-03-31 |
| Walleye Capital LLC | Institution | 81.963 | 0,30% | US$ 3,07M | 2026-03-31 |