| TCG Crossover Management, LLC | Institution | 11.111.111 | 7,24% | US$ 36,67M | 2026-05-27 |
| BlackRock, Inc. | Institution | 9.263.312 | 6,04% | US$ 30,57M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 8.889.000 | 5,79% | US$ 29,33M | 2026-05-27 |
| RA Capital Healthcare Fund, L.P. | Institution | 8.889.000 | 5,79% | US$ 29,33M | 2026-05-27 |
| Commodore Capital Master LP | Institution | 8.889.000 | 5,79% | US$ 29,33M | 2026-05-26 |
| Commodore Capital LP | Institution | 8.889.000 | 5,79% | US$ 29,33M | 2026-05-26 |
| Vanguard Capital Management, LLC | Institution | 4.204.369 | 2,74% | US$ 13,87M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 3.972.160 | 2,59% | US$ 13,11M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 3.148.570 | 2,05% | US$ 10,39M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.311.789 | 1,51% | US$ 7,63M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.076.122 | 1,35% | US$ 6,85M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.943.893 | 1,27% | US$ 6,41M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 1.926.997 | 1,26% | US$ 6,36M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 1.903.318 | 1,24% | US$ 6,28M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1.817.507 | 1,18% | US$ 6,00M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.549.063 | 1,01% | US$ 5,11M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.457.715 | 0,95% | US$ 4,81M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 1.336.647 | 0,87% | US$ 4,41M | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 1.293.848 | 0,84% | US$ 4,27M | 2026-03-31 |
| Kennedy Capital Management LLC | Institution | 1.052.457 | 0,69% | US$ 3,47M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 861.326 | 0,56% | US$ 2,84M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 742.443 | 0,48% | US$ 2,45M | 2026-03-31 |
| Mackenzie Financial Corporation | Institution | 730.054 | 0,48% | US$ 2,41M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 662.389 | 0,43% | US$ 2,19M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 614.036 | 0,40% | US$ 2,03M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 582.309 | 0,38% | US$ 1,92M | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 434.413 | 0,28% | US$ 1,43M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 406.038 | 0,26% | US$ 1,34M | 2026-03-31 |
| UBS Asset Management AG | Institution | 394.234 | 0,26% | US$ 1,30M | 2026-03-31 |
| Morgan Stanley | Institution | 342.696 | 0,22% | US$ 1,13M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 323.493 | 0,21% | US$ 1,07M | 2026-03-31 |