| T. Rowe Price Group, Inc. | Institution | 33.114.174 | 20,03% | US$ 735,47M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 13.647.376 | 8,26% | US$ 303,11M | 2026-03-31 |
| BlackRock, Inc. | Institution | 11.699.749 | 7,08% | US$ 259,85M | 2026-03-31 |
| FMR LLC | Institution | 8.908.949 | 5,39% | US$ 197,87M | 2026-03-31 |
| Atlas Venture Advisors, Inc. | Institution | 7.577.554 | 4,58% | US$ 168,30M | 2026-05-06 |
| Orbis Investment Management Limited | Institution | 6.762.231 | 4,09% | US$ 150,19M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.653.746 | 4,02% | US$ 147,78M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 6.405.069 | 3,87% | US$ 142,26M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 5.196.597 | 3,14% | US$ 115,42M | 2025-01-31 |
| Atlas Venture Fund XI, L.P. | Institution | 4.891.456 | 2,96% | US$ 108,64M | 2026-05-06 |
| Perceptive Advisors LLC | Institution | 4.668.839 | 2,82% | US$ 103,69M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 4.615.144 | 2,79% | US$ 102,50M | 2026-03-31 |
| Forbion Capital Partners B.V. | Institution | 4.196.573 | 2,54% | US$ 93,21M | 2026-04-22 |
| Vanguard Portfolio Management, LLC | Institution | 4.162.041 | 2,52% | US$ 92,44M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 4.000.000 | 2,42% | US$ 88,84M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.504.114 | 2,12% | US$ 77,83M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.282.000 | 1,99% | US$ 72,89M | 2024-09-30 |
| Armistice Capital LLC | Institution | 3.175.110 | 1,92% | US$ 70,52M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 3.153.082 | 1,91% | US$ 70,03M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 3.133.237 | 1,90% | US$ 69,59M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 2.917.884 | 1,77% | US$ 64,81M | 2026-03-31 |
| Artal Group S.A. | Institution | 2.229.125 | 1,35% | US$ 49,51M | 2026-03-31 |
| VR Management, LLC | Institution | 2.173.913 | 1,32% | US$ 48,28M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 2.000.000 | 1,21% | US$ 44,42M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1.993.918 | 1,21% | US$ 44,28M | 2026-03-31 |
| Samlyn Capital, LLC | Institution | 1.922.543 | 1,16% | US$ 42,70M | 2026-03-31 |
| Braidwell LP | Institution | 1.681.998 | 1,02% | US$ 37,36M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 1.652.972 | 1,00% | US$ 36,71M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 1.633.897 | 0,99% | US$ 36,29M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1.557.466 | 0,94% | US$ 34,59M | 2026-03-31 |
| Atlas Venture Opportunity Fund II, L.P. | Institution | 1.549.288 | 0,94% | US$ 34,41M | 2026-05-06 |
| Aberdeen Group Plc | Institution | 1.430.384 | 0,87% | US$ 31,77M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1.408.152 | 0,85% | US$ 31,28M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1.400.000 | 0,85% | US$ 31,09M | 2026-03-31 |
| Fiera Capital Corporation | Institution | 1.380.620 | 0,84% | US$ 30,66M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.359.169 | 0,82% | US$ 30,19M | 2026-03-31 |