| Octagon Capital Advisors LP | Institution | 2.236.732 | 8,67% | US$ 14,43M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 2.230.178 | 8,64% | US$ 14,38M | 2026-03-31 |
| Empery Asset Management, LP | Institution | 1.968.879 | 7,63% | US$ 12,70M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 1.917.995 | 7,43% | US$ 12,37M | 2025-12-31 |
| Bleichroeder LP | Institution | 1.662.500 | 6,44% | US$ 10,72M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 1.066.050 | 4,13% | US$ 6,88M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 995.371 | 3,86% | US$ 6,42M | 2026-03-31 |
| Lynx1 Capital Management LP | Institution | 985.113 | 3,82% | US$ 6,35M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 910.740 | 3,53% | US$ 5,87M | 2026-03-31 |
| Readout Capital, LP | Institution | 886.437 | 3,44% | US$ 5,72M | 2025-06-30 |
| Affinity Asset Advisors, LLC | Institution | 597.946 | 2,32% | US$ 3,86M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 426.293 | 1,65% | US$ 2,75M | 2024-09-30 |
| Marshall Wace LLP | Institution | 415.671 | 1,61% | US$ 2,68M | 2026-03-31 |
| Novartis AG | Institution | 413.581 | 1,60% | US$ 2,67M | 2025-06-30 |
| Benjamin Weinstein | Insider | 395.489 | 1,53% | US$ 2,55M | 2025-03-18 |
| Two Sigma Investments, LP | Institution | 307.790 | 1,19% | US$ 1,99M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 287.090 | 1,11% | US$ 1,85M | 2026-03-31 |
| Mr. Michael Amoroso | Insider | 243.392 | 0,94% | US$ 1,57M | 2026-03-25 |
| Renaissance Technologies LLC | Institution | 223.177 | 0,86% | US$ 1,44M | 2026-03-31 |
| BlackRock, Inc. | Institution | 199.761 | 0,77% | US$ 1,29M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 179.140 | 0,69% | US$ 1,16M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 155.626 | 0,60% | US$ 1,00M | 2026-03-31 |
| Corient Private Wealth LLC | Institution | 143.852 | 0,56% | US$ 927,85k | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 138.825 | 0,54% | US$ 895,42k | 2026-03-31 |
| Dr. Jefferson Smith | Insider | 129.857 | 0,50% | US$ 837,58k | 2026-02-18 |
| Mr. John Kelly | Insider | 125.883 | 0,49% | US$ 811,95k | 2026-03-25 |
| Morgan Stanley | Institution | 122.277 | 0,47% | US$ 788,69k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 115.952 | 0,45% | US$ 747,89k | 2026-03-31 |
| Commonwealth Equity Services, LLC | Institution | 112.671 | 0,44% | US$ 726,73k | 2026-03-31 |
| UBS Asset Management AG | Institution | 81.133 | 0,31% | US$ 523,31k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 76.069 | 0,29% | US$ 490,65k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 72.942 | 0,28% | US$ 470,48k | 2026-03-31 |
| The Quarry LP | Institution | 68.311 | 0,26% | US$ 440,61k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 64.462 | 0,25% | US$ 415,78k | 2026-03-31 |
| Mr. Dario Scimeca | Insider | 56.457 | 0,22% | US$ 364,15k | 2026-03-25 |
| Leap Investments LP | Institution | 49.413 | 0,19% | US$ 318,71k | 2026-03-31 |
| Mr. Kevin Buehler | Insider | 49.137 | 0,19% | US$ 316,93k | 2026-05-20 |
| Jacob Asset Management of New York LLC | Institution | 47.089 | 0,18% | US$ 303,72k | 2026-02-28 |
| Mr. Geno Germano | Insider | 44.883 | 0,17% | US$ 289,50k | 2026-05-20 |
| Acadian Asset Management LLC | Institution | 44.768 | 0,17% | US$ 288,75k | 2026-03-31 |
| Ms. Melinda Brown | Insider | 44.346 | 0,17% | US$ 286,03k | 2026-05-20 |