| BlackRock, Inc. | Institution | 8.480.230 | 7,78% | US$ 194,62M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 8.176.721 | 7,50% | US$ 187,66M | 2024-09-30 |
| Driehaus Capital Management LLC | Institution | 5.911.889 | 5,42% | US$ 135,68M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 5.000.000 | 4,58% | US$ 114,75M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.556.041 | 3,26% | US$ 81,61M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 3.000.000 | 2,75% | US$ 68,85M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.495.399 | 2,29% | US$ 57,27M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.471.873 | 2,27% | US$ 56,73M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2.440.000 | 2,24% | US$ 56,00M | 2026-03-31 |
| Commodore Capital LP | Institution | 2.000.000 | 1,83% | US$ 45,90M | 2026-03-31 |
| FMR LLC | Institution | 1.808.453 | 1,66% | US$ 41,50M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 1.738.110 | 1,59% | US$ 39,89M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 1.676.540 | 1,54% | US$ 38,48M | 2025-12-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 1.594.717 | 1,46% | US$ 36,60M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.333.442 | 1,22% | US$ 30,60M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 1.304.749 | 1,20% | US$ 29,94M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 1.293.629 | 1,19% | US$ 29,69M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.274.221 | 1,17% | US$ 29,24M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.201.610 | 1,10% | US$ 27,58M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.200.825 | 1,10% | US$ 27,56M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.172.966 | 1,08% | US$ 26,92M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 1.150.000 | 1,05% | US$ 26,39M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.096.978 | 1,01% | US$ 25,18M | 2026-03-31 |
| Holocene Advisors, LP | Institution | 1.091.967 | 1,00% | US$ 25,06M | 2026-03-31 |
| AWM Investment Company Inc | Institution | 1.076.893 | 0,99% | US$ 24,71M | 2026-03-31 |
| Catalio Capital Management, LP | Institution | 1.037.984 | 0,95% | US$ 23,82M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 966.608 | 0,89% | US$ 22,18M | 2026-03-31 |
| Artal Group S.A. | Institution | 919.493 | 0,84% | US$ 21,10M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 872.665 | 0,80% | US$ 20,03M | 2026-03-31 |
| Millennium Management LLC | Institution | 846.896 | 0,78% | US$ 19,44M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 808.715 | 0,74% | US$ 18,56M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 804.000 | 0,74% | US$ 18,45M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 798.987 | 0,73% | US$ 18,34M | 2026-03-31 |
| BNY Asset Management | Institution | 752.922 | 0,69% | US$ 17,28M | 2026-03-31 |
| Woodline Partners LP | Institution | 752.792 | 0,69% | US$ 17,28M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 686.895 | 0,63% | US$ 15,76M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 686.162 | 0,63% | US$ 15,75M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 598.500 | 0,55% | US$ 13,74M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 575.937 | 0,53% | US$ 13,22M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 546.783 | 0,50% | US$ 12,55M | 2026-03-31 |