| FMR LLC | Institution | 31.955.637 | 14,68% | US$ 101,62M | 2026-03-31 |
| Longitude Capital Management Co., LLC | Institution | 15.288.461 | 7,02% | US$ 48,62M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 15.013.093 | 6,90% | US$ 47,74M | 2026-03-31 |
| Longitude Venture Partners V, L.P. | Institution | 12.458.461 | 5,72% | US$ 39,62M | 2026-03-31 |
| Longitude Capital Partners V, L.P. | Institution | 11.538.461 | 5,30% | US$ 36,69M | 2025-05-13 |
| Point72 Asset Management, L.P. | Institution | 10.864.581 | 4,99% | US$ 34,55M | 2026-04-15 |
| Bank of America Corporation | Institution | 10.202.785 | 4,69% | US$ 32,44M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 10.098.824 | 4,64% | US$ 32,11M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 10.098.824 | 4,64% | US$ 32,11M | 2026-03-31 |
| VR Management, LLC | Institution | 9.982.124 | 4,59% | US$ 31,74M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 8.733.118 | 4,01% | US$ 27,77M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 7.663.568 | 3,52% | US$ 24,37M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 5.663.408 | 2,60% | US$ 18,01M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 5.406.193 | 2,48% | US$ 17,19M | 2026-03-31 |
| BlackRock, Inc. | Institution | 5.228.280 | 2,40% | US$ 16,63M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 4.975.826 | 2,29% | US$ 15,82M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 4.550.000 | 2,09% | US$ 14,47M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 4.449.932 | 2,04% | US$ 14,15M | 2026-03-31 |
| Marshall Wace LLP | Institution | 4.138.176 | 1,90% | US$ 13,16M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.660.190 | 1,68% | US$ 11,64M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3.582.985 | 1,65% | US$ 11,39M | 2026-03-31 |
| Artal Group S.A. | Institution | 3.457.711 | 1,59% | US$ 11,00M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 3.410.190 | 1,57% | US$ 10,84M | 2026-03-31 |
| UBS Asset Management AG | Institution | 3.309.555 | 1,52% | US$ 10,52M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 3.188.514 | 1,46% | US$ 10,14M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 3.067.864 | 1,41% | US$ 9,76M | 2026-03-31 |
| Longitude 103.8 East, L.P. | Institution | 2.830.000 | 1,30% | US$ 9,00M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 2.710.156 | 1,24% | US$ 8,62M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 2.249.583 | 1,03% | US$ 7,15M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.107.644 | 0,97% | US$ 6,70M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.066.612 | 0,95% | US$ 6,57M | 2026-03-31 |
| Woodline Partners LP | Institution | 2.000.825 | 0,92% | US$ 6,36M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.930.920 | 0,89% | US$ 6,14M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.917.627 | 0,88% | US$ 6,10M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.439.714 | 0,66% | US$ 4,58M | 2026-03-31 |
| Gilder Gagnon Howe & Co. LLC | Institution | 1.120.309 | 0,51% | US$ 3,56M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.102.883 | 0,51% | US$ 3,51M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 1.085.790 | 0,50% | US$ 3,45M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 1.085.398 | 0,50% | US$ 3,45M | 2026-03-31 |