| Tang Capital Management, LLC | Institution | 16.790.809 | 9,32% | US$ 35,76M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 15.219.994 | 8,45% | US$ 32,42M | 2026-03-31 |
| Caduceus Private Investments V, L.P. | Institution | 15.219.994 | 8,45% | US$ 32,42M | 2025-08-13 |
| Suvretta Capital Management, LLC | Institution | 14.307.379 | 7,94% | US$ 30,47M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 12.229.050 | 6,79% | US$ 26,05M | 2025-08-13 |
| Vivo Capital, LLC | Institution | 9.545.466 | 5,30% | US$ 20,33M | 2026-03-31 |
| BlackRock, Inc. | Institution | 9.505.653 | 5,28% | US$ 20,25M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 8.995.979 | 5,00% | US$ 19,16M | 2025-09-30 |
| Adage Capital Management, L.P. | Institution | 8.486.500 | 4,71% | US$ 18,08M | 2026-03-31 |
| Enavate Sciences | Institution | 7.788.150 | 4,32% | US$ 16,59M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.694.976 | 3,72% | US$ 14,26M | 2026-03-31 |
| Blackstone Inc. | Institution | 6.126.182 | 3,40% | US$ 13,05M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 6.037.175 | 3,35% | US$ 12,86M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 5.994.810 | 3,33% | US$ 12,77M | 2024-12-31 |
| Dr. Thomas Schuetz | Insider | 5.909.586 | 3,28% | US$ 12,59M | 2026-03-31 |
| Tang Capital Partners, LP | Institution | 4.669.934 | 2,59% | US$ 9,95M | 2025-01-08 |
| RTW Investments, LP | Institution | 4.186.599 | 2,32% | US$ 8,92M | 2026-03-31 |
| Mr. Mark Lampert | Insider | 4.142.020 | 2,30% | US$ 8,82M | 2026-03-31 |
| BVF Partners L.P. | Institution | 3.622.822 | 2,01% | US$ 7,72M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 3.606.000 | 2,00% | US$ 7,68M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.565.770 | 1,98% | US$ 7,60M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 3.305.308 | 1,84% | US$ 7,04M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 3.150.000 | 1,75% | US$ 6,71M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 3.028.951 | 1,68% | US$ 6,45M | 2026-03-31 |
| CHI Advisors LLC | Institution | 2.941.525 | 1,63% | US$ 6,27M | 2026-03-31 |
| Borealis Ventures | Institution | 2.749.256 | 1,53% | US$ 5,86M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 2.550.356 | 1,42% | US$ 5,43M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.530.975 | 1,41% | US$ 5,39M | 2026-03-31 |
| Borealis Granite Fund | Institution | 2.348.976 | 1,30% | US$ 5,00M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 2.056.161 | 1,14% | US$ 4,38M | 2026-03-31 |
| Braidwell LP | Institution | 1.965.106 | 1,09% | US$ 4,19M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 1.857.848 | 1,03% | US$ 3,96M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.824.357 | 1,01% | US$ 3,89M | 2026-03-31 |
| Impresa Management LLC | Institution | 1.710.498 | 0,95% | US$ 3,64M | 2026-03-31 |
| Royce & Associates, LP | Institution | 1.619.798 | 0,90% | US$ 3,45M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.596.815 | 0,89% | US$ 3,40M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 1.514.504 | 0,84% | US$ 3,23M | 2026-03-31 |
| Birchview Capital, LP | Institution | 1.465.867 | 0,81% | US$ 3,12M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.350.000 | 0,75% | US$ 2,88M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 1.348.259 | 0,75% | US$ 2,87M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.119.090 | 0,62% | US$ 2,38M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.082.651 | 0,60% | US$ 2,31M | 2026-03-31 |
| Schonfeld Strategic Advisors LLC | Institution | 1.076.004 | 0,60% | US$ 2,29M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.048.558 | 0,58% | US$ 2,23M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 998.140 | 0,55% | US$ 2,13M | 2026-03-31 |