| Wellington Management Group LLP | Institution | 8.560.476 | 10,91% | US$ 256,22M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 5.840.567 | 7,44% | US$ 174,81M | 2026-03-31 |
| BlackRock, Inc. | Institution | 5.369.885 | 6,84% | US$ 160,72M | 2026-03-31 |
| FMR LLC | Institution | 3.747.750 | 4,77% | US$ 112,17M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 3.229.939 | 4,11% | US$ 96,67M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 3.028.335 | 3,86% | US$ 90,64M | 2025-09-30 |
| Vanguard Capital Management, LLC | Institution | 2.960.895 | 3,77% | US$ 88,62M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.804.168 | 3,57% | US$ 83,93M | 2026-03-31 |
| Commodore Capital LP | Institution | 2.696.616 | 3,44% | US$ 80,71M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.086.332 | 2,66% | US$ 62,44M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 1.788.016 | 2,28% | US$ 53,52M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 1.758.357 | 2,24% | US$ 52,63M | 2025-12-31 |
| Geode Capital Management, LLC | Institution | 1.688.074 | 2,15% | US$ 50,52M | 2026-03-31 |
| Braidwell LP | Institution | 1.356.082 | 1,73% | US$ 40,59M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 1.283.979 | 1,64% | US$ 38,43M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.253.532 | 1,60% | US$ 37,52M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 1.224.165 | 1,56% | US$ 36,64M | 2026-03-31 |
| Novo Holdings A/S | Institution | 1.200.000 | 1,53% | US$ 35,92M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 1.200.000 | 1,53% | US$ 35,92M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.059.534 | 1,35% | US$ 31,71M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.037.000 | 1,32% | US$ 31,04M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 1.013.648 | 1,29% | US$ 30,34M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 923.696 | 1,18% | US$ 27,65M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 865.000 | 1,10% | US$ 25,89M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 856.310 | 1,09% | US$ 25,63M | 2026-03-31 |
| Bank of America Corporation | Institution | 698.502 | 0,89% | US$ 20,91M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 665.370 | 0,85% | US$ 19,91M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 654.852 | 0,83% | US$ 19,60M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 650.270 | 0,83% | US$ 19,46M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 629.252 | 0,80% | US$ 18,83M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 577.267 | 0,74% | US$ 17,28M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 545.486 | 0,69% | US$ 16,33M | 2026-03-31 |
| Woodline Partners LP | Institution | 500.127 | 0,64% | US$ 14,97M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 500.000 | 0,64% | US$ 14,97M | 2026-03-31 |