| Lynx1 Capital Management LP | Institution | 8.963.500 | 14,58% | US$ 165,65M | 2026-03-31 |
| Lynx1 Master Fund LP | Institution | 8.963.500 | 14,58% | US$ 165,65M | 2025-10-28 |
| MPM BioImpact LLC | Institution | 7.648.268 | 12,44% | US$ 141,34M | 2026-03-31 |
| BVF Partners L.P. | Institution | 5.750.683 | 9,36% | US$ 106,27M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.449.805 | 7,24% | US$ 82,23M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 3.140.696 | 5,11% | US$ 58,04M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 3.114.132 | 5,07% | US$ 57,55M | 2026-03-31 |
| Deerfield Partners, LP | Institution | 2.927.013 | 4,76% | US$ 54,09M | 2025-09-30 |
| State Street Global Advisors, Inc. | Institution | 2.544.115 | 4,14% | US$ 47,02M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.483.034 | 4,04% | US$ 45,89M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 2.272.849 | 3,70% | US$ 42,00M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.029.719 | 3,30% | US$ 37,51M | 2026-03-31 |
| CHI Advisors LLC | Institution | 1.909.764 | 3,11% | US$ 35,29M | 2026-03-31 |
| RTW Investments, LP | Institution | 1.705.960 | 2,78% | US$ 31,53M | 2026-03-31 |
| VR Management, LLC | Institution | 1.379.965 | 2,25% | US$ 25,50M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.368.268 | 2,23% | US$ 25,29M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.193.410 | 1,94% | US$ 22,05M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 1.141.145 | 1,86% | US$ 21,09M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 1.112.803 | 1,81% | US$ 20,56M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.049.581 | 1,71% | US$ 19,40M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 906.028 | 1,47% | US$ 16,74M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 905.376 | 1,47% | US$ 16,73M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 796.781 | 1,30% | US$ 14,72M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 781.260 | 1,27% | US$ 14,44M | 2026-03-31 |
| Twin Focus Capital Partners, LLC | Institution | 595.489 | 0,97% | US$ 11,00M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 552.553 | 0,90% | US$ 10,21M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 530.000 | 0,86% | US$ 9,79M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 522.047 | 0,85% | US$ 9,65M | 2026-03-31 |
| Bank of America Corporation | Institution | 516.724 | 0,84% | US$ 9,55M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 449.258 | 0,73% | US$ 8,30M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 432.893 | 0,70% | US$ 8,00M | 2026-03-31 |
| Morgan Stanley | Institution | 430.113 | 0,70% | US$ 7,95M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 420.742 | 0,68% | US$ 7,78M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 410.200 | 0,67% | US$ 7,58M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 406.786 | 0,66% | US$ 7,52M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 386.169 | 0,63% | US$ 7,14M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 367.906 | 0,60% | US$ 6,80M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 357.354 | 0,58% | US$ 6,60M | 2026-03-31 |
| Millennium Management LLC | Institution | 346.582 | 0,56% | US$ 6,40M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 342.852 | 0,56% | US$ 6,34M | 2026-03-31 |