| Baker Bros. Advisors LP | Institution | 7.915.792 | 16,23% | US$ 854,51M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 7.211.484 | 14,79% | US$ 778,48M | 2026-03-20 |
| Avoro Capital Advisors LLC | Institution | 3.375.000 | 6,92% | US$ 364,33M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 3.127.200 | 6,41% | US$ 337,58M | 2026-03-31 |
| RTW Investments, LP | Institution | 3.039.621 | 6,23% | US$ 328,13M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.711.532 | 5,56% | US$ 292,71M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 2.670.597 | 5,48% | US$ 288,29M | 2025-07-30 |
| New Enterprise Associates, Inc. | Institution | 2.285.561 | 4,69% | US$ 246,73M | 2026-03-31 |
| NEA 18 Venture Growth Equity, L.P. | Institution | 2.285.561 | 4,69% | US$ 246,73M | 2026-03-06 |
| Vanguard Capital Management, LLC | Institution | 1.782.894 | 3,66% | US$ 192,46M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 1.714.000 | 3,51% | US$ 185,03M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.518.705 | 3,11% | US$ 163,94M | 2026-03-31 |
| Morgan Stanley | Institution | 1.292.521 | 2,65% | US$ 139,53M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 1.284.378 | 2,63% | US$ 138,65M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.279.816 | 2,62% | US$ 138,16M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1.050.000 | 2,15% | US$ 113,35M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 891.070 | 1,83% | US$ 96,19M | 2026-03-31 |
| The Toronto-Dominion Bank | Institution | 882.758 | 1,81% | US$ 95,29M | 2026-03-31 |
| 667, L.P. | Institution | 704.308 | 1,44% | US$ 76,03M | 2026-03-20 |
| Bank of America Corporation | Institution | 694.097 | 1,42% | US$ 74,93M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 662.147 | 1,36% | US$ 71,48M | 2026-03-31 |
| Apis Capital Advisors, LLC | Institution | 515.000 | 1,06% | US$ 55,59M | 2026-03-31 |
| Nearwater Capital Markets, Limited | Institution | 473.100 | 0,97% | US$ 51,07M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 464.328 | 0,95% | US$ 50,12M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 457.070 | 0,94% | US$ 49,34M | 2026-03-31 |
| Lord, Abbett & Co. LLC | Institution | 439.221 | 0,90% | US$ 47,41M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 428.952 | 0,88% | US$ 46,31M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 400.000 | 0,82% | US$ 43,18M | 2024-12-31 |
| Holocene Advisors, LP | Institution | 369.979 | 0,76% | US$ 39,94M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 366.175 | 0,75% | US$ 39,53M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 357.903 | 0,73% | US$ 38,64M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 318.766 | 0,65% | US$ 34,41M | 2026-03-31 |
| Capitolis Advisors LLC | Institution | 316.500 | 0,65% | US$ 34,17M | 2026-03-31 |
| Pfizer Venture Investments LLC | Institution | 295.652 | 0,61% | US$ 31,92M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 293.892 | 0,60% | US$ 31,73M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 291.171 | 0,60% | US$ 31,43M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 281.904 | 0,58% | US$ 30,43M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 280.324 | 0,57% | US$ 30,26M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 253.366 | 0,52% | US$ 27,35M | 2026-03-31 |
| UBS Asset Management AG | Institution | 250.958 | 0,51% | US$ 27,09M | 2026-03-31 |