| BlackRock, Inc. | Institution | 4.522.065 | 8,75% | US$ 125,94M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 3.336.409 | 6,46% | US$ 92,92M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.760.385 | 5,34% | US$ 76,88M | 2026-03-31 |
| ARK Investment Management LLC | Institution | 2.227.556 | 4,31% | US$ 62,04M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 2.191.000 | 4,24% | US$ 61,02M | 2026-03-31 |
| Braidwell LP | Institution | 2.173.146 | 4,21% | US$ 60,52M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.160.457 | 4,18% | US$ 60,17M | 2026-03-31 |
| Boston Partners Global Investors, Inc. | Institution | 1.883.534 | 3,65% | US$ 52,46M | 2026-03-31 |
| Gagnon Securities, LLC | Institution | 1.761.874 | 3,41% | US$ 49,07M | 2026-03-31 |
| Chevy Chase Trust Company | Institution | 1.504.075 | 2,91% | US$ 41,89M | 2026-03-31 |
| Amova Asset Management Co., Ltd. | Institution | 1.475.126 | 2,86% | US$ 41,08M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.461.914 | 2,83% | US$ 40,71M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.254.114 | 2,43% | US$ 34,93M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.184.398 | 2,29% | US$ 32,99M | 2026-03-31 |
| Ophir Asset Management Pty Ltd | Institution | 988.051 | 1,91% | US$ 27,52M | 2026-03-31 |
| Blue Water Life Science Advisors, LP | Institution | 935.000 | 1,81% | US$ 26,04M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 874.908 | 1,69% | US$ 24,37M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 864.468 | 1,67% | US$ 24,08M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 851.433 | 1,65% | US$ 23,71M | 2026-03-31 |
| First Eagle Investment Management, LLC | Institution | 575.365 | 1,11% | US$ 16,02M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 558.336 | 1,08% | US$ 15,55M | 2026-03-31 |
| Royce & Associates, LP | Institution | 553.197 | 1,07% | US$ 15,41M | 2026-03-31 |
| Kent Lake PR LLC | Institution | 550.000 | 1,06% | US$ 15,32M | 2025-09-30 |
| Gagnon Investment Associates LLC | Institution | 532.892 | 1,03% | US$ 14,84M | 2025-12-31 |
| Gagnon Advisors, LLC | Institution | 532.892 | 1,03% | US$ 14,84M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 531.870 | 1,03% | US$ 14,81M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 510.405 | 0,99% | US$ 14,21M | 2026-03-31 |
| Paragon Associates, Ltd. | Institution | 500.000 | 0,97% | US$ 13,93M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 486.668 | 0,94% | US$ 13,55M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 472.146 | 0,91% | US$ 13,15M | 2026-03-31 |
| Jackson National Asset Management, LLC | Institution | 470.868 | 0,91% | US$ 13,11M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 458.301 | 0,89% | US$ 12,76M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 457.970 | 0,89% | US$ 12,75M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 454.508 | 0,88% | US$ 12,66M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 417.744 | 0,81% | US$ 11,63M | 2026-03-31 |
| Zweig-DiMenna Associates, Inc. | Institution | 390.255 | 0,76% | US$ 10,87M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 385.044 | 0,75% | US$ 10,72M | 2026-03-31 |