| BlackRock, Inc. | Institution | 4.522.096 | 8,75% | US$ 132,00M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 3.336.409 | 6,46% | US$ 97,39M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.760.385 | 5,34% | US$ 80,58M | 2026-03-31 |
| ARK Investment Management LLC | Institution | 2.227.556 | 4,31% | US$ 65,02M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 2.191.000 | 4,24% | US$ 63,96M | 2026-03-31 |
| Braidwell LP | Institution | 2.173.146 | 4,21% | US$ 63,43M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.160.457 | 4,18% | US$ 63,06M | 2026-03-31 |
| Boston Partners Global Investors, Inc. | Institution | 1.883.534 | 3,65% | US$ 54,98M | 2026-03-31 |
| Gagnon Securities, LLC | Institution | 1.761.874 | 3,41% | US$ 51,43M | 2026-03-31 |
| Chevy Chase Trust Company | Institution | 1.504.075 | 2,91% | US$ 43,90M | 2026-03-31 |
| Amova Asset Management Co., Ltd. | Institution | 1.475.126 | 2,86% | US$ 43,06M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.461.914 | 2,83% | US$ 42,67M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.254.114 | 2,43% | US$ 36,61M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.184.398 | 2,29% | US$ 34,57M | 2026-03-31 |
| Ophir Asset Management Pty Ltd | Institution | 988.051 | 1,91% | US$ 28,84M | 2026-03-31 |
| Blue Water Life Science Advisors, LP | Institution | 935.000 | 1,81% | US$ 27,29M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 874.908 | 1,69% | US$ 25,54M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 864.468 | 1,67% | US$ 25,23M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 851.433 | 1,65% | US$ 24,85M | 2026-03-31 |
| Mr. John Hanna | Insider | 661.959 | 1,28% | US$ 19,32M | 2026-06-29 |
| First Eagle Investment Management, LLC | Institution | 575.365 | 1,11% | US$ 16,79M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 558.336 | 1,08% | US$ 16,30M | 2026-03-31 |
| Royce & Associates, LP | Institution | 553.197 | 1,07% | US$ 16,15M | 2026-03-31 |
| Gagnon Investment Associates LLC | Institution | 532.892 | 1,03% | US$ 15,56M | 2025-12-31 |
| Gagnon Advisors, LLC | Institution | 532.892 | 1,03% | US$ 15,56M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 531.870 | 1,03% | US$ 15,53M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 510.405 | 0,99% | US$ 14,90M | 2026-03-31 |
| Paragon Associates, Ltd. | Institution | 500.000 | 0,97% | US$ 14,60M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 486.668 | 0,94% | US$ 14,21M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 472.146 | 0,91% | US$ 13,78M | 2026-03-31 |
| Jackson National Asset Management, LLC | Institution | 470.868 | 0,91% | US$ 13,74M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 458.301 | 0,89% | US$ 13,38M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 457.970 | 0,89% | US$ 13,37M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 454.508 | 0,88% | US$ 13,27M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 417.744 | 0,81% | US$ 12,19M | 2026-03-31 |
| Zweig-DiMenna Associates, Inc. | Institution | 390.255 | 0,76% | US$ 11,39M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 385.044 | 0,75% | US$ 11,24M | 2026-03-31 |