| FMR LLC | Institution | 4.849.811 | 12,78% | US$ 90,93M | 2026-03-31 |
| TPG Capital, L.P. | Institution | 3.967.422 | 10,46% | US$ 74,39M | 2026-03-31 |
| Longitude Capital Management Co., LLC | Institution | 2.475.110 | 6,52% | US$ 46,41M | 2026-04-06 |
| Longitude Venture Partners IV, L.P. | Institution | 2.475.110 | 6,52% | US$ 46,41M | 2026-04-06 |
| Ally Bridge Group-WTT Global Life Science Capital Partners, L.P. | Institution | 2.441.267 | 6,43% | US$ 45,77M | 2024-12-31 |
| The Global Value Investment Portfolio Management Pte Ltd. | Institution | 2.368.345 | 6,24% | US$ 44,41M | 2026-04-06 |
| the u.life fund | Institution | 2.350.936 | 6,20% | US$ 44,08M | 2026-04-06 |
| Red Tree Venture Capital | Institution | 2.205.661 | 5,81% | US$ 41,36M | 2026-03-31 |
| Red Tree Venture Fund, L.P. | Institution | 2.031.565 | 5,35% | US$ 38,09M | 2024-12-31 |
| BlackRock, Inc. | Institution | 1.813.155 | 4,78% | US$ 34,00M | 2026-03-31 |
| Kcm Capital, Inc. | Institution | 1.400.000 | 3,69% | US$ 26,25M | 2026-03-31 |
| ACP Trust | Institution | 1.276.999 | 3,37% | US$ 23,94M | 2026-04-06 |
| BNY Asset Management | Institution | 1.150.853 | 3,03% | US$ 21,58M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.137.132 | 3,00% | US$ 21,32M | 2026-03-31 |
| Ally Bridge Group | Institution | 991.268 | 2,61% | US$ 18,59M | 2026-03-31 |
| Federated Hermes, Inc. | Institution | 939.464 | 2,48% | US$ 17,61M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 786.055 | 2,07% | US$ 14,74M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 756.751 | 1,99% | US$ 14,19M | 2026-03-31 |
| TimesSquare Capital Management, LLC | Institution | 716.468 | 1,89% | US$ 13,43M | 2026-03-31 |
| Dr. Josef Parvizi | Insider | 713.824 | 1,88% | US$ 13,38M | 2026-04-06 |
| Dr. Xingjuan Chao | Insider | 670.579 | 1,77% | US$ 12,57M | 2026-05-05 |
| Geode Capital Management, LLC | Institution | 611.977 | 1,61% | US$ 11,47M | 2026-03-31 |
| Millennium Management LLC | Institution | 552.021 | 1,45% | US$ 10,35M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 525.432 | 1,38% | US$ 9,85M | 2026-03-31 |
| Royce & Associates, LP | Institution | 515.720 | 1,36% | US$ 9,67M | 2026-03-31 |
| Massachusetts Financial Services Company | Institution | 508.490 | 1,34% | US$ 9,53M | 2026-03-31 |
| Silvercrest Asset Management Group LLC | Institution | 489.742 | 1,29% | US$ 9,18M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 411.031 | 1,08% | US$ 7,71M | 2026-03-31 |
| Redmile Group, LLC | Institution | 386.786 | 1,02% | US$ 7,25M | 2026-03-31 |
| Peregrine Capital Management, LLC | Institution | 348.219 | 0,92% | US$ 6,53M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 326.032 | 0,86% | US$ 6,11M | 2026-03-31 |
| Creek Drive Management Group LLC | Institution | 323.000 | 0,85% | US$ 6,06M | 2026-03-31 |
| Allspring Global Investments, LLC | Institution | 296.080 | 0,78% | US$ 5,55M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 288.114 | 0,76% | US$ 5,40M | 2026-03-31 |
| Bank of America Corporation | Institution | 225.871 | 0,60% | US$ 4,24M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 222.090 | 0,59% | US$ 4,16M | 2026-03-31 |