| Nippon Shinyaku Co., Ltd. | Institution | 4.944.429 | 8,54% | US$ 138,20M | 2025-03-26 |
| Suvretta Capital Management, LLC | Institution | 3.818.600 | 6,59% | US$ 106,73M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.421.815 | 5,91% | US$ 95,64M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 3.399.900 | 5,87% | US$ 95,03M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 2.917.420 | 5,04% | US$ 81,54M | 2026-02-19 |
| State Street Global Advisors, Inc. | Institution | 2.181.901 | 3,77% | US$ 60,98M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.027.732 | 3,50% | US$ 56,68M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 1.507.844 | 2,60% | US$ 42,14M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.118.326 | 1,93% | US$ 31,26M | 2026-03-31 |
| Jones Hill Capital LP | Institution | 909.207 | 1,57% | US$ 25,41M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 843.083 | 1,46% | US$ 23,56M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 821.179 | 1,42% | US$ 22,95M | 2026-03-31 |
| FMR LLC | Institution | 772.640 | 1,33% | US$ 21,60M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 590.000 | 1,02% | US$ 16,49M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 566.081 | 0,98% | US$ 15,82M | 2026-03-31 |
| J. Goldman & Co., L.P. | Institution | 541.522 | 0,94% | US$ 15,14M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 539.232 | 0,93% | US$ 15,07M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 528.015 | 0,91% | US$ 14,76M | 2026-03-31 |
| UBS Asset Management AG | Institution | 448.361 | 0,77% | US$ 12,53M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 417.543 | 0,72% | US$ 11,67M | 2026-03-31 |
| Bank of America Corporation | Institution | 415.483 | 0,72% | US$ 11,61M | 2026-03-31 |
| Morgan Stanley | Institution | 408.483 | 0,71% | US$ 11,42M | 2026-03-31 |
| Mercer Global Advisors Inc. | Institution | 402.999 | 0,70% | US$ 11,26M | 2026-03-31 |
| DG Capital Management, LLC | Institution | 392.096 | 0,68% | US$ 10,96M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 379.214 | 0,65% | US$ 10,60M | 2026-03-31 |
| Millennium Management LLC | Institution | 356.354 | 0,62% | US$ 9,96M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 320.098 | 0,55% | US$ 8,95M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 315.275 | 0,54% | US$ 8,81M | 2026-03-31 |
| Barclays PLC | Institution | 311.000 | 0,54% | US$ 8,69M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 297.123 | 0,51% | US$ 8,30M | 2026-03-31 |
| RTW Investments, LP | Institution | 250.000 | 0,43% | US$ 6,99M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 229.763 | 0,40% | US$ 6,42M | 2026-03-31 |
| Moody Aldrich Partners, LLC | Institution | 226.028 | 0,39% | US$ 6,32M | 2026-03-31 |
| Trexquant Investment LP | Institution | 222.413 | 0,38% | US$ 6,22M | 2026-03-31 |
| Dr. Linda Marbán | Insider | 212.024 | 0,37% | US$ 5,93M | 2025-03-26 |
| HBK Sorce Advisory LLC | Institution | 204.837 | 0,35% | US$ 5,73M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 200.000 | 0,35% | US$ 5,59M | 2026-03-31 |
| Raymond James Financial, Inc. | Institution | 196.300 | 0,34% | US$ 5,49M | 2026-03-31 |