AstraZeneca Says Trial Shows Enhertu Reduced Risk of Breast Cancer Progression, Death by 50%
06 Juni 2022 - 8:57AM
Dow Jones News
By Kyle Morris
AstraZeneca PLC said Monday that a Phase 3 trial has shown that
Enhertu reduced the risk of breast cancer progression or death by
50% when compared with chemotherapy in patients with HER2-low
metastatic breast cancer with HR-positive and HR-negative disease
forms.
The Anglo-Swedish pharmaceutical company said that Enhertu, or
trastuzumab deruxtecan, met its primary endpoint of
progression-free survival in patients with hormone
receptor-positive disease, reducing the risk of disease progression
or death by 49% versus chemotherapy.
Enhertu improved median overall survival by more than six months
compared with chemotherapy in all patients evaluated, it said.
HER2 is a tyrosine kinase receptor growth-promoting protein
expressed on the surface of many types of tumors, including breast,
and is a biomarker expressed in breast cancer tumors.
Write to Kyle Morris at kyle.morris@dowjones.com
(END) Dow Jones Newswires
June 06, 2022 02:42 ET (06:42 GMT)
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