| FMR LLC | Institution | 11.950.304 | 14,93% | US$ 52,82M | 2026-03-31 |
| BlackRock, Inc. | Institution | 8.435.437 | 10,54% | US$ 37,28M | 2026-03-31 |
| BML Investment Partners, L.P. | Institution | 7.490.000 | 9,36% | US$ 33,11M | 2025-12-31 |
| BML Capital Management, LLC | Institution | 7.058.657 | 8,82% | US$ 31,20M | 2026-03-31 |
| Dr. Jean-Pierre Sommadossi | Insider | 6.633.855 | 8,29% | US$ 29,32M | 2026-02-03 |
| Tang Capital Management, LLC | Institution | 4.814.700 | 6,02% | US$ 21,28M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.246.124 | 4,06% | US$ 14,35M | 2026-03-31 |
| Mr. Bradley Radoff | Insider | 3.165.100 | 3,96% | US$ 13,99M | 2025-04-16 |
| Bain Capital Life Sciences Investors, LLC | Institution | 2.360.638 | 2,95% | US$ 10,43M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.864.164 | 2,33% | US$ 8,24M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.747.706 | 2,18% | US$ 7,72M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.694.635 | 2,12% | US$ 7,49M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.582.817 | 1,98% | US$ 7,00M | 2026-03-31 |
| JEC II Associates LLC | Institution | 1.300.000 | 1,62% | US$ 5,75M | 2025-04-16 |
| Dimensional Fund Advisors LP | Institution | 1.255.484 | 1,57% | US$ 5,55M | 2026-03-31 |
| Rosalind Advisors, Inc. | Institution | 1.171.855 | 1,46% | US$ 5,18M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.166.400 | 1,46% | US$ 5,16M | 2026-03-31 |
| Ms. Andrea Corcoran | Insider | 823.576 | 1,03% | US$ 3,64M | 2026-04-24 |
| JP Morgan Asset Management | Institution | 814.746 | 1,02% | US$ 3,60M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 596.709 | 0,75% | US$ 2,64M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 585.025 | 0,73% | US$ 2,59M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 557.579 | 0,70% | US$ 2,46M | 2026-03-31 |
| Mr. Franklin Berger | Insider | 506.497 | 0,63% | US$ 2,24M | 2026-04-24 |
| Vanguard Fiduciary Trust Company | Institution | 484.705 | 0,61% | US$ 2,14M | 2026-03-31 |
| Morgan Stanley | Institution | 455.734 | 0,57% | US$ 2,01M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 418.296 | 0,52% | US$ 1,85M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 393.598 | 0,49% | US$ 1,74M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 379.314 | 0,47% | US$ 1,68M | 2026-03-31 |
| CM Management, LLC | Institution | 355.000 | 0,44% | US$ 1,57M | 2026-03-31 |
| Millennium Management LLC | Institution | 349.932 | 0,44% | US$ 1,55M | 2026-03-31 |
| Banque Pictet & Cie SA | Institution | 345.077 | 0,43% | US$ 1,53M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 322.600 | 0,40% | US$ 1,43M | 2026-03-31 |
| Mr. Braden Leonard | Insider | 320.000 | 0,40% | US$ 1,41M | 2025-12-31 |
| Irenic Capital Management LP | Institution | 301.699 | 0,38% | US$ 1,33M | 2026-03-31 |