| Suvretta Capital Management, LLC | Institution | 4.401.083 | 9,45% | US$ 140,92M | 2026-03-31 |
| Infinitum Asset Management, LLC | Institution | 4.148.923 | 8,91% | US$ 132,85M | 2026-03-31 |
| Hillhouse Investment Management, Ltd. | Institution | 3.929.117 | 8,44% | US$ 125,81M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 3.027.328 | 6,50% | US$ 96,94M | 2026-03-31 |
| FMR LLC | Institution | 3.015.861 | 6,48% | US$ 96,57M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.530.301 | 5,43% | US$ 81,02M | 2026-03-31 |
| HBM Partners Ltd. | Institution | 2.195.014 | 4,71% | US$ 70,28M | 2025-10-08 |
| Hillhouse Venture Fund V, L.P. | Institution | 2.169.625 | 4,66% | US$ 69,47M | 2025-12-10 |
| Eli Lilly Investment Consulting (Shanghai) Co., Ltd. | Institution | 2.046.123 | 4,39% | US$ 65,52M | 2025-04-21 |
| LAV Fund VI, L.P. | Institution | 2.006.123 | 4,31% | US$ 64,24M | 2025-04-21 |
| Octagon Capital Advisors LP | Institution | 1.971.054 | 4,23% | US$ 63,11M | 2026-03-31 |
| Novo Holdings A/S | Institution | 1.942.142 | 4,17% | US$ 62,19M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 1.820.609 | 3,91% | US$ 58,30M | 2024-11-26 |
| Sofinnova Investments, Inc. | Institution | 1.696.752 | 3,64% | US$ 54,33M | 2026-03-31 |
| Sofinnova Venture Partners XI, L.P. | Institution | 1.696.752 | 3,64% | US$ 54,33M | 2026-04-21 |
| Vanguard Capital Management, LLC | Institution | 1.528.893 | 3,28% | US$ 48,96M | 2026-03-31 |
| Orbimed Private Investments VIII, LP | Institution | 1.513.664 | 3,25% | US$ 48,47M | 2025-08-13 |
| Orbimed Asia Partners IV, L.P. | Institution | 1.513.664 | 3,25% | US$ 48,47M | 2025-08-13 |
| General Catalyst Group Management, LLC | Institution | 1.494.786 | 3,21% | US$ 47,86M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.421.415 | 3,05% | US$ 45,51M | 2026-03-31 |
| Octagon Private Opportunities Fund LP | Institution | 1.194.387 | 2,56% | US$ 38,24M | 2024-09-30 |
| Vivo Capital, LLC | Institution | 885.916 | 1,90% | US$ 28,37M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 803.652 | 1,73% | US$ 25,73M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 782.000 | 1,68% | US$ 25,04M | 2024-09-30 |
| Point72 Asset Management, L.P. | Institution | 748.195 | 1,61% | US$ 23,96M | 2026-03-31 |
| HongShan Capital Advisors Limited | Institution | 663.308 | 1,42% | US$ 21,24M | 2026-03-31 |
| Ms. Robin LaChapelle | Insider | 530.213 | 1,14% | US$ 16,98M | 2025-07-11 |
| The Goldman Sachs Group, Inc. | Institution | 525.033 | 1,13% | US$ 16,81M | 2026-03-31 |
| Pleasant Lake Partners LLC | Institution | 499.990 | 1,07% | US$ 16,01M | 2026-03-31 |
| UBS Asset Management AG | Institution | 497.620 | 1,07% | US$ 15,93M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 426.281 | 0,92% | US$ 13,65M | 2026-03-31 |
| Millennium Management LLC | Institution | 425.923 | 0,91% | US$ 13,64M | 2026-03-31 |
| The MAKS Yao Trust | Institution | 394.477 | 0,85% | US$ 12,63M | 2026-04-21 |
| D. E. Shaw & Co., L.P. | Institution | 368.795 | 0,79% | US$ 11,81M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 350.000 | 0,75% | US$ 11,21M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 328.394 | 0,71% | US$ 10,52M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 268.812 | 0,58% | US$ 8,61M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 258.772 | 0,56% | US$ 8,29M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 253.852 | 0,55% | US$ 8,13M | 2026-03-31 |
| Nomura Holdings, Inc. | Institution | 242.050 | 0,52% | US$ 7,75M | 2026-03-31 |
| Dr. Zhengbin Yao | Insider | 218.661 | 0,47% | US$ 7,00M | 2026-04-21 |