| Avoro Capital Advisors LLC | Institution | 10.699.999 | 7,60% | US$ 848,19M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.496.130 | 4,61% | US$ 514,95M | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 3.342.493 | 2,37% | US$ 264,96M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2.667.267 | 1,89% | US$ 211,43M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 2.275.000 | 1,62% | US$ 180,34M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1.992.783 | 1,41% | US$ 157,97M | 2026-03-31 |
| Invesco Capital Management LLC | Institution | 1.751.985 | 1,24% | US$ 138,88M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.655.837 | 1,18% | US$ 131,26M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.615.476 | 1,15% | US$ 128,06M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 1.573.297 | 1,12% | US$ 124,72M | 2026-03-31 |
| Invesco Ltd. | Institution | 1.528.662 | 1,09% | US$ 121,18M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 1.436.990 | 1,02% | US$ 113,91M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 1.273.266 | 0,90% | US$ 100,93M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.214.899 | 0,86% | US$ 96,31M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 1.190.335 | 0,85% | US$ 94,36M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.183.838 | 0,84% | US$ 93,84M | 2026-03-31 |
| Hood River Capital Management LLC | Institution | 1.056.534 | 0,75% | US$ 83,75M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.036.495 | 0,74% | US$ 82,16M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 836.981 | 0,59% | US$ 66,35M | 2026-03-31 |
| Western Financial Corporation | Institution | 820.239 | 0,58% | US$ 65,02M | 2026-03-31 |
| Voya Investment Management LLC | Institution | 656.129 | 0,47% | US$ 52,01M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 650.599 | 0,46% | US$ 51,57M | 2026-03-31 |
| Arrowstreet Capital, Limited Partnership | Institution | 587.125 | 0,42% | US$ 46,54M | 2026-03-31 |
| RTW Investments, LP | Institution | 585.682 | 0,42% | US$ 46,43M | 2026-03-31 |
| Summit Partners Public Asset Management, LLC | Institution | 540.144 | 0,38% | US$ 42,82M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 472.870 | 0,34% | US$ 37,48M | 2026-03-31 |